TY - JOUR
T1 - Stem cells in dentistry - Part II
T2 - Clinical applications
AU - Egusa, Hiroshi
AU - Sonoyama, Wataru
AU - Nishimura, Masahiro
AU - Atsuta, Ikiru
AU - Akiyama, Kentaro
N1 - Funding Information:
This review article was written as a project proposed by the Journal of Prosthodontic Research (JPR) Editorial Committee under the support of the Japan Prosthodontic Society (JPS) . The authors thank Prof. Takuo Kuboki, the Editor-in-Chief of the JPR, and Prof. Kiyoshi Koyano, the President of the JPS, for their valuable support to accomplish this work. Support was also received from a Grant-in-Aid for Young Scientists ( A22689049 : H.E. and A22689050 : W.S.) and for Scientific Research ( B22390367 : M.N.) from the Japan Society for the Promotion of Science .
PY - 2012/10
Y1 - 2012/10
N2 - New technologies that facilitate solid alveolar ridge augmentation are receiving considerable attention in the field of prosthodontics because of the growing requirement for esthetic and functional reconstruction by dental implant treatments. Recently, several studies have demonstrated potential advantages for stem-cell-based therapies in regenerative treatments. Mesenchymal stem/stromal cells (MSCs) are now an excellent candidate for tissue replacement therapies, and tissue engineering approaches and chair-side cellular grafting approaches using autologous MSCs represent the clinical state of the art for stem-cell-based alveolar bone regeneration. Basic studies have revealed that crosstalk between implanted donor cells and recipient immune cells plays a key role in determining clinical success that may involve the recently observed immunomodulatory properties of MSCs. Part II of this review first overviews progress in regenerative dentistry to consider the implications of the stem cell technology in dentistry and then highlights cutting-edge stem-cell-based alveolar bone regenerative therapies. Factors that affect stem-cell-based bone regeneration as related to the local immune response are then discussed. Additionally, pre-clinical stem cell studies for the regeneration of teeth and other oral organs as well as possible applications of MSC-based immunotherapy in dentistry are outlined. Finally, the marketing of stem cell technology in dental stem cell banks with a view toward future regenerative therapies is introduced.
AB - New technologies that facilitate solid alveolar ridge augmentation are receiving considerable attention in the field of prosthodontics because of the growing requirement for esthetic and functional reconstruction by dental implant treatments. Recently, several studies have demonstrated potential advantages for stem-cell-based therapies in regenerative treatments. Mesenchymal stem/stromal cells (MSCs) are now an excellent candidate for tissue replacement therapies, and tissue engineering approaches and chair-side cellular grafting approaches using autologous MSCs represent the clinical state of the art for stem-cell-based alveolar bone regeneration. Basic studies have revealed that crosstalk between implanted donor cells and recipient immune cells plays a key role in determining clinical success that may involve the recently observed immunomodulatory properties of MSCs. Part II of this review first overviews progress in regenerative dentistry to consider the implications of the stem cell technology in dentistry and then highlights cutting-edge stem-cell-based alveolar bone regenerative therapies. Factors that affect stem-cell-based bone regeneration as related to the local immune response are then discussed. Additionally, pre-clinical stem cell studies for the regeneration of teeth and other oral organs as well as possible applications of MSC-based immunotherapy in dentistry are outlined. Finally, the marketing of stem cell technology in dental stem cell banks with a view toward future regenerative therapies is introduced.
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U2 - 10.1016/j.jpor.2012.10.001
DO - 10.1016/j.jpor.2012.10.001
M3 - Review article
C2 - 23137671
AN - SCOPUS:84870247060
VL - 56
SP - 229
EP - 248
JO - Nippon Hotetsu Shika Gakkai zasshi
JF - Nippon Hotetsu Shika Gakkai zasshi
SN - 1883-1958
IS - 4
ER -