Abstract
The syntheses of all possible conformational isomers using a protection-deprotection method with a benzyl group and metal template effects are reported. The numbers of chiral isomers are 17 for tetra-O-substituted calix[4]arenes, 9 for tri-O-substituted calix[4]arenes, 3 for di-O-substituted calix[4]arenes, and 0 for mono-O-substituted calix[4]arenes. The synthesis of chiral calix[4]arenes is possible through the introduction of a substituent into the m-position of a phenol unit or by the use of dissymetric `stapling reaction' in proximal phenol units.
| Original language | English |
|---|---|
| Pages (from-to) | 189-205 |
| Number of pages | 17 |
| Journal | Supramolecular Science |
| Volume | 3 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jan 1 1996 |
All Science Journal Classification (ASJC) codes
- Engineering(all)
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Otsuka, H., & Shinkai, S. (1996). Stereochemical control of calixarenes useful as rigid and conformationally diversiform platforms for molecular design. Supramolecular Science, 3(4), 189-205. https://doi.org/10.1016/S0968-5677(96)00038-7