Stereodivergent direct catalytic asymmetric mannich-type reactions of α-isothiocyanato ester with ketimines

Gang Lu, Tatsuhiko Yoshino, Hiroyuki Morimoto, Shigeki Matsunaga, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

124 Citations (Scopus)

Abstract

Now accessible: Sterically hindered vicinal tetrasubstituted carbon stereocenters, which are not accessible by asymmetric hydrogenation, were constructed by a catalytic asymmetric C-C bond formation (see scheme; Dpp=diphenylphosphinoyl). By changing the Group 2 metal center, stereodivergent access to α,β-tetrasubstituted α,β-diamino esters was realized.

Original languageEnglish
Pages (from-to)4382-4385
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number19
DOIs
Publication statusPublished - May 2 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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