Stereospecificity of hydroxyl group at C-20 in antiproliferative action of ginsenoside Rh2 on prostate cancer cells

Jie Liu, Kuniyoshi Shimizu, Hongshan Yu, Chunzhi Zhang, Fengxie Jin, Ryuichiro Kondo

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Prostate cancer is the fifth most common neoplasm worldwide, and the second most common cancer among men. Ginsenosides, the main component of ginseng, have been known for their medicinal effects such as anti-inflammatory and anti-proliferative activities. In this study, we investigated the inhibitory effects of ginsenosides (ginsenoside 20(R)-Rh2 and ginsenoside 20(S)-Rh2) on prostate cancer cells in vitro. Only ginsenoside 20(S)-Rh2 showed proliferation inhibition on androgen-dependent and -independent prostate cancer cells. These results implied that the stereochemistry of the hydroxyl group at C-20 may play an important role in antitumor activities.

Original languageEnglish
Pages (from-to)902-905
Number of pages4
JournalFitoterapia
Volume81
Issue number7
DOIs
Publication statusPublished - Oct 1 2010

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Ginsenosides
Hydroxyl Radical
Prostatic Neoplasms
Panax
Second Primary Neoplasms
Androgens
Anti-Inflammatory Agents
ginsenoside Rh2
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Stereospecificity of hydroxyl group at C-20 in antiproliferative action of ginsenoside Rh2 on prostate cancer cells. / Liu, Jie; Shimizu, Kuniyoshi; Yu, Hongshan; Zhang, Chunzhi; Jin, Fengxie; Kondo, Ryuichiro.

In: Fitoterapia, Vol. 81, No. 7, 01.10.2010, p. 902-905.

Research output: Contribution to journalArticle

Liu, Jie ; Shimizu, Kuniyoshi ; Yu, Hongshan ; Zhang, Chunzhi ; Jin, Fengxie ; Kondo, Ryuichiro. / Stereospecificity of hydroxyl group at C-20 in antiproliferative action of ginsenoside Rh2 on prostate cancer cells. In: Fitoterapia. 2010 ; Vol. 81, No. 7. pp. 902-905.
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