TY - JOUR
T1 - Sterilization of small vial using electron cyclotron resonance plasma
AU - Nishikawa, Tatsuya
AU - Abe, Norihito
AU - Yonesu, Akira
AU - Hayashi, Nobuya
N1 - Publisher Copyright:
© 2018
PY - 2018/11
Y1 - 2018/11
N2 - The sterilization of a small vial using electron cyclotron resonance (ECR) plasma was investigated. The ECR plasma was generated throughout the inside of the small vial, which was sealed with nonwoven fabric, by using magnetic configuration in which the ECR point was located inside the small vial. Moreover, it was demonstrated that the temperature of the small vial was finely controlled by the pulse width and pulse frequency of the pulsed microwave power. A biological indicator (BI), Geobacillus Stearothermophilus, containing 1 × 105 spores present inside the small vial was successfully inactivated in a total treatment time of about 14 min while maintaining treatment temperature of less than 65 °C.
AB - The sterilization of a small vial using electron cyclotron resonance (ECR) plasma was investigated. The ECR plasma was generated throughout the inside of the small vial, which was sealed with nonwoven fabric, by using magnetic configuration in which the ECR point was located inside the small vial. Moreover, it was demonstrated that the temperature of the small vial was finely controlled by the pulse width and pulse frequency of the pulsed microwave power. A biological indicator (BI), Geobacillus Stearothermophilus, containing 1 × 105 spores present inside the small vial was successfully inactivated in a total treatment time of about 14 min while maintaining treatment temperature of less than 65 °C.
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U2 - 10.1016/j.vacuum.2018.06.069
DO - 10.1016/j.vacuum.2018.06.069
M3 - Article
AN - SCOPUS:85052282065
VL - 157
SP - 100
EP - 104
JO - Vacuum
JF - Vacuum
SN - 0042-207X
ER -