Steroid 5α-reductase inhibitory activity of condensed tannins from woody plants

Jie Liu, Ryo Ando, Kuniyoshi Shimizu, Koh Hashida, Rei Makino, Seiji Ohara, Ryuichiro Kondo

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12 Citations (Scopus)

Abstract

In humans, steroid 5α-reductase is involved in the development of benign prostatic hyperplasia (BPH). We tested the steroid 5α-reductase inhibitory activity of the 70% acetone extract of woody plants. The tannin polymer prepared from the 70% acetone extract showed the highest steroid 5α-reductase inhibitory activity. Furthermore, the steroid 5α-reductase inhibitory activity of tannins was not affected by the addition of superoxide dismutase or catalase. It was concluded that the steroid 5α-reductase inhibitory activity of condensed tannin was caused by binding to the steroid 5α-reductase, rather than from the peroxide/superoxide produced by tannins. The tannins, prepared from tree barks, with potential for steroid 5α-reductase inhibitory activity might be advantageous in therapy for steroid 5α-reductase diseases such as BPH or prostate cancer.

Original languageEnglish
Pages (from-to)68-75
Number of pages8
JournalJournal of Wood Science
Volume54
Issue number1
DOIs
Publication statusPublished - Jan 1 2008

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All Science Journal Classification (ASJC) codes

  • Biomaterials

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