Steroid 5α-reductase inhibitory activity of condensed tannins from woody plants

Jie Liu, Ryo Ando, Kuniyoshi Shimizu, Koh Hashida, Rei Makino, Seiji Ohara, Ryuichiro Kondo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In humans, steroid 5α-reductase is involved in the development of benign prostatic hyperplasia (BPH). We tested the steroid 5α-reductase inhibitory activity of the 70% acetone extract of woody plants. The tannin polymer prepared from the 70% acetone extract showed the highest steroid 5α-reductase inhibitory activity. Furthermore, the steroid 5α-reductase inhibitory activity of tannins was not affected by the addition of superoxide dismutase or catalase. It was concluded that the steroid 5α-reductase inhibitory activity of condensed tannin was caused by binding to the steroid 5α-reductase, rather than from the peroxide/superoxide produced by tannins. The tannins, prepared from tree barks, with potential for steroid 5α-reductase inhibitory activity might be advantageous in therapy for steroid 5α-reductase diseases such as BPH or prostate cancer.

Original languageEnglish
Pages (from-to)68-75
Number of pages8
JournalJournal of Wood Science
Volume54
Issue number1
DOIs
Publication statusPublished - Jan 1 2008

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Proanthocyanidins
Oxidoreductases
Steroids
Tannins
Acetone
Peroxides
Plant Extracts
Superoxides
Catalase
Superoxide Dismutase
Polymers

All Science Journal Classification (ASJC) codes

  • Biomaterials

Cite this

Steroid 5α-reductase inhibitory activity of condensed tannins from woody plants. / Liu, Jie; Ando, Ryo; Shimizu, Kuniyoshi; Hashida, Koh; Makino, Rei; Ohara, Seiji; Kondo, Ryuichiro.

In: Journal of Wood Science, Vol. 54, No. 1, 01.01.2008, p. 68-75.

Research output: Contribution to journalArticle

Liu, Jie ; Ando, Ryo ; Shimizu, Kuniyoshi ; Hashida, Koh ; Makino, Rei ; Ohara, Seiji ; Kondo, Ryuichiro. / Steroid 5α-reductase inhibitory activity of condensed tannins from woody plants. In: Journal of Wood Science. 2008 ; Vol. 54, No. 1. pp. 68-75.
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