Steroidal saponins from Chlorophytum orchidastrum

Debabrata Acharya, Anne Claire Mitaine-Offer, Nutan Kaushik, Tomofumi Miyamoto, Thomas Paululat, Jean François Mirjolet, Olivier Duchamp, Marie Aleth Lacaille-Dubois

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19 Citations (Scopus)

Abstract

Six new spirostane-type saponins (1-6), named orchidastrosides A-F, and chloromaloside D were isolated from an ethanol extract of the roots of Chlorophytum orchidastrum. The saponins have neotigogenin or neogitogenin as the aglycon and oligosaccharidic chains possessing seven to nine sugar units. Their structures were elucidated mainly by 2D NMR spectroscopic analyses (COSY, TOCSY, NOESY, HSQC, and HMBC) and FABMS and HRESIMS. Compounds 1-6 were tested for cytotoxicity against two human colon cancer cell lines, HCT 116 and HT-29.

Original languageEnglish
Pages (from-to)7-11
Number of pages5
JournalJournal of Natural Products
Volume73
Issue number1
DOIs
Publication statusPublished - Jan 22 2010

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • Cite this

    Acharya, D., Mitaine-Offer, A. C., Kaushik, N., Miyamoto, T., Paululat, T., Mirjolet, J. F., Duchamp, O., & Lacaille-Dubois, M. A. (2010). Steroidal saponins from Chlorophytum orchidastrum. Journal of Natural Products, 73(1), 7-11. https://doi.org/10.1021/np900443q