Steroidal saponins from Chlorophytum orchidastrum

Debabrata Acharya; Anne Claire Mitaine-Offer; Nutan Kaushik; Tomofumi Miyamoto; Thomas Paululat; Jean François Mirjolet; Olivier Duchamp; Marie Aleth Lacaille-Dubois

doi:10.1021/np900443q

Steroidal saponins from Chlorophytum orchidastrum

Debabrata Acharya, Anne Claire Mitaine-Offer, Nutan Kaushik, Tomofumi Miyamoto, Thomas Paululat, Jean François Mirjolet, Olivier Duchamp, Marie Aleth Lacaille-Dubois

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Six new spirostane-type saponins (1-6), named orchidastrosides A-F, and chloromaloside D were isolated from an ethanol extract of the roots of Chlorophytum orchidastrum. The saponins have neotigogenin or neogitogenin as the aglycon and oligosaccharidic chains possessing seven to nine sugar units. Their structures were elucidated mainly by 2D NMR spectroscopic analyses (COSY, TOCSY, NOESY, HSQC, and HMBC) and FABMS and HRESIMS. Compounds 1-6 were tested for cytotoxicity against two human colon cancer cell lines, HCT 116 and HT-29.

Original language	English
Pages (from-to)	7-11
Number of pages	5
Journal	Journal of Natural Products
Volume	73
Issue number	1
DOIs	https://doi.org/10.1021/np900443q
Publication status	Published - Jan 22 2010

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np900443q

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abstract = "Six new spirostane-type saponins (1-6), named orchidastrosides A-F, and chloromaloside D were isolated from an ethanol extract of the roots of Chlorophytum orchidastrum. The saponins have neotigogenin or neogitogenin as the aglycon and oligosaccharidic chains possessing seven to nine sugar units. Their structures were elucidated mainly by 2D NMR spectroscopic analyses (COSY, TOCSY, NOESY, HSQC, and HMBC) and FABMS and HRESIMS. Compounds 1-6 were tested for cytotoxicity against two human colon cancer cell lines, HCT 116 and HT-29.",

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AU - Acharya, Debabrata

AU - Mitaine-Offer, Anne Claire

AU - Kaushik, Nutan

AU - Miyamoto, Tomofumi

AU - Paululat, Thomas

AU - Mirjolet, Jean François

AU - Duchamp, Olivier

AU - Lacaille-Dubois, Marie Aleth

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AB - Six new spirostane-type saponins (1-6), named orchidastrosides A-F, and chloromaloside D were isolated from an ethanol extract of the roots of Chlorophytum orchidastrum. The saponins have neotigogenin or neogitogenin as the aglycon and oligosaccharidic chains possessing seven to nine sugar units. Their structures were elucidated mainly by 2D NMR spectroscopic analyses (COSY, TOCSY, NOESY, HSQC, and HMBC) and FABMS and HRESIMS. Compounds 1-6 were tested for cytotoxicity against two human colon cancer cell lines, HCT 116 and HT-29.

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Steroidal saponins from Chlorophytum orchidastrum

Abstract

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