Steroidal saponins from dioscorea preussii

Turibio Kuiate Tabopda, Anne Claire Mitaine-Offer, Chiaki Tanaka, Tomofumi Miyamoto, Jean François Mirjolet, Olivier Duchamp, Bonaventure Tchaleu Ngadjui, Marie Aleth Lacaille-Dubois

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9 Citations (Scopus)

Abstract

Three new steroidal saponins, named diospreussinosides A-C (1-3), along with two known ones (4, 5) were isolated from rhizomes of Dioscorea preussii. Their structures were elucidated mainly by 1D and 2D NMR spectroscopic analysis and mass spectrometry as (25S)-17α,25-dihydroxyspirost-5-en-3β-yl-O- α-l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 4)-β-d-glucopyranoside (1), (25S)-17α,25-dihydroxyspirost-5-en- 3β-yl-O-α-l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 4)-[α-l-rhamnopyranosyl-(1 → 2)]-β-d-glucopyranoside (2), and (24S,25R)-17α,24,25-trihydroxyspirost-5-en-3β-yl-O-α- l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 4)-[α-l-rhamnopyranosyl-(1 → 2)]-β-d-glucopyranoside (3). The spirostane-type skeleton of compound 3 possessing an unusual dihydroxylation pattern on the F-ring is reported for the first time. Cytotoxicity of compounds 2-5 was evaluated against two human colon carcinoma cell lines (HT-29 and HCT 116).

Original languageEnglish
Pages (from-to)198-203
Number of pages6
JournalFitoterapia
Volume97
DOIs
Publication statusPublished - Sep 2014

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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  • Cite this

    Tabopda, T. K., Mitaine-Offer, A. C., Tanaka, C., Miyamoto, T., Mirjolet, J. F., Duchamp, O., Ngadjui, B. T., & Lacaille-Dubois, M. A. (2014). Steroidal saponins from dioscorea preussii. Fitoterapia, 97, 198-203. https://doi.org/10.1016/j.fitote.2014.06.006