Steroidal saponins from Smilax medica and their antifungal activity

Marc Sautour, Tomofumi Miyamoto, Marie Aleth Lacaille-Dubois

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38 Citations (Scopus)

Abstract

Three new steroidal saponins (1-3) were isolated from the roots of Smilax medica, together with the known disporoside A (4). The structures of the new compounds were elucidated mainly by extensive spectroscopic analysis (1D and 2D NMR, FABMS, and HRESIMS). Compounds 1,2, and 4 demonstrated weak antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata, and C. tropicalis, with MIC values between 12.5 and 50 μg/mL.

Original languageEnglish
Pages (from-to)1489-1493
Number of pages5
JournalJournal of Natural Products
Volume68
Issue number10
DOIs
Publication statusPublished - Oct 1 2005

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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