Steroidal saponins from Smilax medica and their antifungal activity

Marc Sautour; Tomofumi Miyamoto; Marie Aleth Lacaille-Dubois

doi:10.1021/np058060b

Steroidal saponins from Smilax medica and their antifungal activity

Marc Sautour, Tomofumi Miyamoto, Marie Aleth Lacaille-Dubois

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Three new steroidal saponins (1-3) were isolated from the roots of Smilax medica, together with the known disporoside A (4). The structures of the new compounds were elucidated mainly by extensive spectroscopic analysis (1D and 2D NMR, FABMS, and HRESIMS). Compounds 1,2, and 4 demonstrated weak antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata, and C. tropicalis, with MIC values between 12.5 and 50 μg/mL.

Original language	English
Pages (from-to)	1489-1493
Number of pages	5
Journal	Journal of Natural Products
Volume	68
Issue number	10
DOIs	https://doi.org/10.1021/np058060b
Publication status	Published - Oct 1 2005

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np058060b

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Steroidal saponins from Smilax medica and their antifungal activity

Abstract

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