Steroidal saponins from the roots of Smilax aspera subsp. mauritanica

Zineddine Belhouchet, Marc Sautour, Tomofumi Miyamoto, Marie Aleth Lacaille-Dubois

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Two new steroidal saponins (1, 2) were isolated from the roots of Smilax aspera subsp. mauritanica (POIR.) ARCANG. (Liliaceae), together with the known curillin G (3), asparagoside E (4), asparoside A (5), asparoside B (6) and the phenolic compound resveratrol (7). Their structures were established mainly on the basis of 600 MHz 2D-NMR spectral data. 3 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (minimum inhibitory concentrations of 25, 25 and 50 μg/ml, respectively) whereas the other compounds were inactive.

Original languageEnglish
Pages (from-to)1324-1327
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume56
Issue number9
DOIs
Publication statusPublished - Sep 1 2008

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Smilax
Liliaceae
Candida
Saponins
Microbial Sensitivity Tests
Candida albicans
Human Activities
Yeast
Yeasts
Nuclear magnetic resonance
resveratrol

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

Cite this

Steroidal saponins from the roots of Smilax aspera subsp. mauritanica. / Belhouchet, Zineddine; Sautour, Marc; Miyamoto, Tomofumi; Lacaille-Dubois, Marie Aleth.

In: Chemical and Pharmaceutical Bulletin, Vol. 56, No. 9, 01.09.2008, p. 1324-1327.

Research output: Contribution to journalArticle

Belhouchet, Zineddine ; Sautour, Marc ; Miyamoto, Tomofumi ; Lacaille-Dubois, Marie Aleth. / Steroidal saponins from the roots of Smilax aspera subsp. mauritanica. In: Chemical and Pharmaceutical Bulletin. 2008 ; Vol. 56, No. 9. pp. 1324-1327.
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