Steroidal saponins from the roots of Smilax aspera subsp. mauritanica

Zineddine Belhouchet, Marc Sautour, Tomofumi Miyamoto, Marie Aleth Lacaille-Dubois

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Two new steroidal saponins (1, 2) were isolated from the roots of Smilax aspera subsp. mauritanica (POIR.) ARCANG. (Liliaceae), together with the known curillin G (3), asparagoside E (4), asparoside A (5), asparoside B (6) and the phenolic compound resveratrol (7). Their structures were established mainly on the basis of 600 MHz 2D-NMR spectral data. 3 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (minimum inhibitory concentrations of 25, 25 and 50 μg/ml, respectively) whereas the other compounds were inactive.

Original languageEnglish
Pages (from-to)1324-1327
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume56
Issue number9
DOIs
Publication statusPublished - Sep 1 2008

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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