Steroidal saponins from two species of dracaena

Guy Beddos Kougan, Tomofumi Miyamoto, Chiaki Tanaka, Thomas Paululat, Jean François Mirjolet, Olivier Duchamp, Beibam Lucas Sondengam, Marie Aleth Lacaille-Dubois

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31 Citations (Scopus)

Abstract

Four new steroidal saponins (1-4) were isolated from the stem and bark of two species of Dracaena: deistelianosides A and B (1 and 2) from D. deisteliana and arboreasaponins A and B (3 and 4) from D. arborea. Six known saponins and one known sapogenin were also isolated. The structures of 1-4 were established as diosgenin 3-O-[3-O-sulfate-α-l-rhamnopyranosyl-(1→4)]-β-d- glucopyranoside (1), 1-O-β-d-xylopyranosyl-(1→2)-[α-l- rhamnopyranosyl-(1→3)]-β-d-fucopyranosyl(23S,24S)-spirosta-5,25(27) -diene-1β,3β,23α,24α-tetrol 24-O-α-l- arabinopyranoside (2), pennogenin-3-O-α-l-rhamnopyranosyl-(1→2)- [α-l-rhamnopyranosyl-(1→3)]-[6-O-acetyl]-β-d-glucopyranoside (3), and 24α-hydroxypennogenin 3-O-α-l-rhamnopyranosyl-(1→2)- [α-l-rhamnopyranosyl-(1→3)]-β-d-glucopyranoside (4) using extensive 1D and 2D NMR spectroscopic analyses and mass spectrometry. Cytotoxic activity of several of these compounds was evaluated against the HT-29 and HCT 116 human colon cancer cell lines.

Original languageEnglish
Pages (from-to)1266-1270
Number of pages5
JournalJournal of Natural Products
Volume73
Issue number7
DOIs
Publication statusPublished - Jul 23 2010

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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