Steroidogenesis in zebrafish and mouse models

Hwei Jan Hsu, Nai Chi Hsu, Meng Chun Hu, Bon Chu Chung

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Steroid hormones regulate physiological homeostasis for salt, sugar, and sex differentiation. All steroids are synthesized from a common precursor, cholesterol, in a step that converts cholesterol to pregnenolone. The enzyme carrying out this first conversion step is CYP11A1. To further investigate the importance of steroid biosynthesis, animal models with defects in the Cyp11a1 gene are used. Mice with targeted disruption of the Cyp11a1 gene produce no steroids with severe adrenal defects. These mice survive during embryogenesis, but die after birth. Zebrafish with a block in cyp11a1 gene function has an earlier defect, presumably because it lacks adequate maternal steroid supply. When cyp11a1 activity was compensated by the injection of antisense morpholino oligos, the embryos have shortened axis and a defect of epibolic cell movement during early embryogenesis. The discovery of steroid function in cell movement is novel, and should provide new insights into our understanding of diverse functions of steroids.

Original languageEnglish
Pages (from-to)160-163
Number of pages4
JournalMolecular and Cellular Endocrinology
Volume248
Issue number1-2
DOIs
Publication statusPublished - Mar 27 2006

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Zebrafish
Steroids
Defects
Genes
Embryonic Development
Cell Movement
Steroid hormones
Cholesterol
Cells
Cholesterol Side-Chain Cleavage Enzyme
Morpholinos
Pregnenolone
Biosynthesis
Sex Differentiation
Sugars
Animals
Salts
Homeostasis
Embryonic Structures
Animal Models

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this

Steroidogenesis in zebrafish and mouse models. / Hsu, Hwei Jan; Hsu, Nai Chi; Hu, Meng Chun; Chung, Bon Chu.

In: Molecular and Cellular Endocrinology, Vol. 248, No. 1-2, 27.03.2006, p. 160-163.

Research output: Contribution to journalArticle

Hsu, Hwei Jan ; Hsu, Nai Chi ; Hu, Meng Chun ; Chung, Bon Chu. / Steroidogenesis in zebrafish and mouse models. In: Molecular and Cellular Endocrinology. 2006 ; Vol. 248, No. 1-2. pp. 160-163.
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