Stimulation of circus movement by activin, bFGF and TGF-β2 in isolated animal cap cells of Xenopus laevis

Itsushi Minoura; Hisashi Nakamura; Kosuke Tashiro; Koichiro Shiokawa

doi:10.1016/0925-4773(94)00303-5

Stimulation of circus movement by activin, bFGF and TGF-β2 in isolated animal cap cells of Xenopus laevis

Itsushi Minoura, Hisashi Nakamura, Kosuke Tashiro, Koichiro Shiokawa

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Lobopodium is a hyaline cytoplasmic protrusion which rotates circumferencially around a cell. This movement is called circus movement, which is seen in dissociated cells of amphibian embryos. Relative abundance of the lobopodia-forming cells changes temporally and spatially within Xenopus embryos, reflecting stage-dependent difference of morphogenetic movements. The lobopodia-forming activity of dissociated animal cap cells was stimulated strongly by activin and bFGF, and weakly by TGF-β2. In addition, activin A was found to stimulate cellular attachment to the substratum when the cultivation lasted long. Thus, mesoderm-inducing growth factors stimulate lobopodia formation and cellular movements which may be necessary for gastrulation and neurulation in Xenopus early embryos.

Original language	English
Pages (from-to)	65-69
Number of pages	5
Journal	Mechanisms of Development
Volume	49
Issue number	1-2
DOIs	https://doi.org/10.1016/0925-4773(94)00303-5
Publication status	Published - Jan 1995
Externally published	Yes

All Science Journal Classification (ASJC) codes

Embryology
Developmental Biology

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title = "Stimulation of circus movement by activin, bFGF and TGF-β2 in isolated animal cap cells of Xenopus laevis",

abstract = "Lobopodium is a hyaline cytoplasmic protrusion which rotates circumferencially around a cell. This movement is called circus movement, which is seen in dissociated cells of amphibian embryos. Relative abundance of the lobopodia-forming cells changes temporally and spatially within Xenopus embryos, reflecting stage-dependent difference of morphogenetic movements. The lobopodia-forming activity of dissociated animal cap cells was stimulated strongly by activin and bFGF, and weakly by TGF-β2. In addition, activin A was found to stimulate cellular attachment to the substratum when the cultivation lasted long. Thus, mesoderm-inducing growth factors stimulate lobopodia formation and cellular movements which may be necessary for gastrulation and neurulation in Xenopus early embryos.",

author = "Itsushi Minoura and Hisashi Nakamura and Kosuke Tashiro and Koichiro Shiokawa",

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T1 - Stimulation of circus movement by activin, bFGF and TGF-β2 in isolated animal cap cells of Xenopus laevis

AU - Minoura, Itsushi

AU - Nakamura, Hisashi

AU - Tashiro, Kosuke

AU - Shiokawa, Koichiro

PY - 1995/1

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AB - Lobopodium is a hyaline cytoplasmic protrusion which rotates circumferencially around a cell. This movement is called circus movement, which is seen in dissociated cells of amphibian embryos. Relative abundance of the lobopodia-forming cells changes temporally and spatially within Xenopus embryos, reflecting stage-dependent difference of morphogenetic movements. The lobopodia-forming activity of dissociated animal cap cells was stimulated strongly by activin and bFGF, and weakly by TGF-β2. In addition, activin A was found to stimulate cellular attachment to the substratum when the cultivation lasted long. Thus, mesoderm-inducing growth factors stimulate lobopodia formation and cellular movements which may be necessary for gastrulation and neurulation in Xenopus early embryos.

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