Abstract
Lobopodium is a hyaline cytoplasmic protrusion which rotates circumferencially around a cell. This movement is called circus movement, which is seen in dissociated cells of amphibian embryos. Relative abundance of the lobopodia-forming cells changes temporally and spatially within Xenopus embryos, reflecting stage-dependent difference of morphogenetic movements. The lobopodia-forming activity of dissociated animal cap cells was stimulated strongly by activin and bFGF, and weakly by TGF-β2. In addition, activin A was found to stimulate cellular attachment to the substratum when the cultivation lasted long. Thus, mesoderm-inducing growth factors stimulate lobopodia formation and cellular movements which may be necessary for gastrulation and neurulation in Xenopus early embryos.
| Original language | English |
|---|---|
| Pages (from-to) | 65-69 |
| Number of pages | 5 |
| Journal | Mechanisms of Development |
| Volume | 49 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Jan 1995 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Embryology
- Developmental Biology
Cite this
Stimulation of circus movement by activin, bFGF and TGF-β2 in isolated animal cap cells of Xenopus laevis. / Minoura, Itsushi; Nakamura, Hisashi; Tashiro, Kosuke; Shiokawa, Koichiro.
In: Mechanisms of Development, Vol. 49, No. 1-2, 01.1995, p. 65-69.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stimulation of circus movement by activin, bFGF and TGF-β2 in isolated animal cap cells of Xenopus laevis
AU - Minoura, Itsushi
AU - Nakamura, Hisashi
AU - Tashiro, Kosuke
AU - Shiokawa, Koichiro
PY - 1995/1
Y1 - 1995/1
N2 - Lobopodium is a hyaline cytoplasmic protrusion which rotates circumferencially around a cell. This movement is called circus movement, which is seen in dissociated cells of amphibian embryos. Relative abundance of the lobopodia-forming cells changes temporally and spatially within Xenopus embryos, reflecting stage-dependent difference of morphogenetic movements. The lobopodia-forming activity of dissociated animal cap cells was stimulated strongly by activin and bFGF, and weakly by TGF-β2. In addition, activin A was found to stimulate cellular attachment to the substratum when the cultivation lasted long. Thus, mesoderm-inducing growth factors stimulate lobopodia formation and cellular movements which may be necessary for gastrulation and neurulation in Xenopus early embryos.
AB - Lobopodium is a hyaline cytoplasmic protrusion which rotates circumferencially around a cell. This movement is called circus movement, which is seen in dissociated cells of amphibian embryos. Relative abundance of the lobopodia-forming cells changes temporally and spatially within Xenopus embryos, reflecting stage-dependent difference of morphogenetic movements. The lobopodia-forming activity of dissociated animal cap cells was stimulated strongly by activin and bFGF, and weakly by TGF-β2. In addition, activin A was found to stimulate cellular attachment to the substratum when the cultivation lasted long. Thus, mesoderm-inducing growth factors stimulate lobopodia formation and cellular movements which may be necessary for gastrulation and neurulation in Xenopus early embryos.
UR - http://www.scopus.com/inward/record.url?scp=0028926435&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028926435&partnerID=8YFLogxK
U2 - 10.1016/0925-4773(94)00303-5
DO - 10.1016/0925-4773(94)00303-5
M3 - Article
C2 - 7748790
AN - SCOPUS:0028926435
VL - 49
SP - 65
EP - 69
JO - Mechanisms of Development
JF - Mechanisms of Development
SN - 0925-4773
IS - 1-2
ER -