Stimulation of circus movement by activin, bFGF and TGF-β2 in isolated animal cap cells of Xenopus laevis

Itsushi Minoura, Hisashi Nakamura, Kosuke Tashiro, Koichiro Shiokawa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Lobopodium is a hyaline cytoplasmic protrusion which rotates circumferencially around a cell. This movement is called circus movement, which is seen in dissociated cells of amphibian embryos. Relative abundance of the lobopodia-forming cells changes temporally and spatially within Xenopus embryos, reflecting stage-dependent difference of morphogenetic movements. The lobopodia-forming activity of dissociated animal cap cells was stimulated strongly by activin and bFGF, and weakly by TGF-β2. In addition, activin A was found to stimulate cellular attachment to the substratum when the cultivation lasted long. Thus, mesoderm-inducing growth factors stimulate lobopodia formation and cellular movements which may be necessary for gastrulation and neurulation in Xenopus early embryos.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalMechanisms of Development
Volume49
Issue number1-2
DOIs
Publication statusPublished - Jan 1 1995
Externally publishedYes

Fingerprint

Activins
Pseudopodia
Xenopus laevis
Embryonic Structures
Xenopus
Neurulation
Gastrulation
Hyalin
Amphibians
Mesoderm
Intercellular Signaling Peptides and Proteins

All Science Journal Classification (ASJC) codes

  • Embryology
  • Developmental Biology

Cite this

Stimulation of circus movement by activin, bFGF and TGF-β2 in isolated animal cap cells of Xenopus laevis. / Minoura, Itsushi; Nakamura, Hisashi; Tashiro, Kosuke; Shiokawa, Koichiro.

In: Mechanisms of Development, Vol. 49, No. 1-2, 01.01.1995, p. 65-69.

Research output: Contribution to journalArticle

Minoura, Itsushi ; Nakamura, Hisashi ; Tashiro, Kosuke ; Shiokawa, Koichiro. / Stimulation of circus movement by activin, bFGF and TGF-β2 in isolated animal cap cells of Xenopus laevis. In: Mechanisms of Development. 1995 ; Vol. 49, No. 1-2. pp. 65-69.
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