Abstract
Gonadotropin-inhibitory hormone (GnIH), first isolated from the brain of the Japanese quail (Coturnix japonica), when centrally administered exerts orexigenic effects in birds. However, the precise mechanisms mediating this effect are poorly understood and limited information is available on this effect in models of body weight dysfunction. Thus, the purpose of the present study was to investigate appetite-associated effects of GnIH in chicks from lines that have been selected for either low or high body weight, and are anorexic or become obese, respectively. Central GnIH injection increased food intake in both lines with a similar magnitude of response. There was no effect on water intake. Hypothalamic GnIH mRNA was greater in the low than high weight lines and was greater in the fasted than fed chicks. GnIH receptor mRNA was similarly expressed in both lines, and was greater in fed than fasted chicks. Thus, although selection for body weight did not alter the effect of GnIH on feeding, fasting increased GnIH mRNA in both lines implying that it is an innate hunger factor.
| Original language | English |
|---|---|
| Pages (from-to) | 96-100 |
| Number of pages | 5 |
| Journal | General and Comparative Endocrinology |
| Volume | 232 |
| DOIs | |
| Publication status | Published - Jun 1 2016 |
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All Science Journal Classification (ASJC) codes
- Animal Science and Zoology
- Endocrinology
Cite this
Stimulation of food intake after central administration of gonadotropin-inhibitory hormone is similar in genetically selected low and high body weight lines of chickens. / McConn, Betty R.; Yi, Jiaqing; Gilbert, Elizabeth R.; Siegel, Paul B.; Chowdhury, Vishwajit S.; Furuse, Mitsuhiro; Cline, Mark A.
In: General and Comparative Endocrinology, Vol. 232, 01.06.2016, p. 96-100.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stimulation of food intake after central administration of gonadotropin-inhibitory hormone is similar in genetically selected low and high body weight lines of chickens
AU - McConn, Betty R.
AU - Yi, Jiaqing
AU - Gilbert, Elizabeth R.
AU - Siegel, Paul B.
AU - Chowdhury, Vishwajit S.
AU - Furuse, Mitsuhiro
AU - Cline, Mark A.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Gonadotropin-inhibitory hormone (GnIH), first isolated from the brain of the Japanese quail (Coturnix japonica), when centrally administered exerts orexigenic effects in birds. However, the precise mechanisms mediating this effect are poorly understood and limited information is available on this effect in models of body weight dysfunction. Thus, the purpose of the present study was to investigate appetite-associated effects of GnIH in chicks from lines that have been selected for either low or high body weight, and are anorexic or become obese, respectively. Central GnIH injection increased food intake in both lines with a similar magnitude of response. There was no effect on water intake. Hypothalamic GnIH mRNA was greater in the low than high weight lines and was greater in the fasted than fed chicks. GnIH receptor mRNA was similarly expressed in both lines, and was greater in fed than fasted chicks. Thus, although selection for body weight did not alter the effect of GnIH on feeding, fasting increased GnIH mRNA in both lines implying that it is an innate hunger factor.
AB - Gonadotropin-inhibitory hormone (GnIH), first isolated from the brain of the Japanese quail (Coturnix japonica), when centrally administered exerts orexigenic effects in birds. However, the precise mechanisms mediating this effect are poorly understood and limited information is available on this effect in models of body weight dysfunction. Thus, the purpose of the present study was to investigate appetite-associated effects of GnIH in chicks from lines that have been selected for either low or high body weight, and are anorexic or become obese, respectively. Central GnIH injection increased food intake in both lines with a similar magnitude of response. There was no effect on water intake. Hypothalamic GnIH mRNA was greater in the low than high weight lines and was greater in the fasted than fed chicks. GnIH receptor mRNA was similarly expressed in both lines, and was greater in fed than fasted chicks. Thus, although selection for body weight did not alter the effect of GnIH on feeding, fasting increased GnIH mRNA in both lines implying that it is an innate hunger factor.
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UR - http://www.scopus.com/inward/citedby.url?scp=84955279516&partnerID=8YFLogxK
U2 - 10.1016/j.ygcen.2016.01.004
DO - 10.1016/j.ygcen.2016.01.004
M3 - Article
C2 - 26764213
AN - SCOPUS:84955279516
VL - 232
SP - 96
EP - 100
JO - General and Comparative Endocrinology
JF - General and Comparative Endocrinology
SN - 0016-6480
ER -