Stimulation of food intake after central administration of gonadotropin-inhibitory hormone is similar in genetically selected low and high body weight lines of chickens

Betty R. McConn, Jiaqing Yi, Elizabeth R. Gilbert, Paul B. Siegel, Vishwajit S. Chowdhury, Mitsuhiro Furuse, Mark A. Cline

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Gonadotropin-inhibitory hormone (GnIH), first isolated from the brain of the Japanese quail (Coturnix japonica), when centrally administered exerts orexigenic effects in birds. However, the precise mechanisms mediating this effect are poorly understood and limited information is available on this effect in models of body weight dysfunction. Thus, the purpose of the present study was to investigate appetite-associated effects of GnIH in chicks from lines that have been selected for either low or high body weight, and are anorexic or become obese, respectively. Central GnIH injection increased food intake in both lines with a similar magnitude of response. There was no effect on water intake. Hypothalamic GnIH mRNA was greater in the low than high weight lines and was greater in the fasted than fed chicks. GnIH receptor mRNA was similarly expressed in both lines, and was greater in fed than fasted chicks. Thus, although selection for body weight did not alter the effect of GnIH on feeding, fasting increased GnIH mRNA in both lines implying that it is an innate hunger factor.

Original languageEnglish
Pages (from-to)96-100
Number of pages5
JournalGeneral and Comparative Endocrinology
Volume232
DOIs
Publication statusPublished - Jun 1 2016

Fingerprint

gonadotropins
Gonadotropins
Chickens
food intake
Eating
Body Weight
hormones
Hormones
chickens
body weight
Coturnix
chicks
Messenger RNA
Hunger
hormone receptors
Appetite
hunger
appetite
Drinking
Birds

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • Endocrinology

Cite this

Stimulation of food intake after central administration of gonadotropin-inhibitory hormone is similar in genetically selected low and high body weight lines of chickens. / McConn, Betty R.; Yi, Jiaqing; Gilbert, Elizabeth R.; Siegel, Paul B.; Chowdhury, Vishwajit S.; Furuse, Mitsuhiro; Cline, Mark A.

In: General and Comparative Endocrinology, Vol. 232, 01.06.2016, p. 96-100.

Research output: Contribution to journalArticle

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AU - Siegel, Paul B.

AU - Chowdhury, Vishwajit S.

AU - Furuse, Mitsuhiro

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