Stimulation of the estrogen axis induces epithelial-mesenchymal transition in human salivary cancer cells

Tomoki Sumida, Akiko Ishikawa, Yoshihide Mori

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Salivary gland cancer is a common type of head and neck cancer characterized by occasional deep invasion and lung metastasis. The precise role of sex steroid hormones in salivary gland cancer is unclear. To address this issue, we investigated whether the estrogen axis modulates salivary adenocarcinoma (SAC) and whether hormone therapy can be an effective treatment. Materials and Methods: The estrogen receptor (ER) was overexpressed in HSG human SAC cells that lack endogenous ER and the cells were treated with and without 17β-estradiol (E2). Results: E2 enhanced malignant phenotypes. Moreover, E2 treatment reduced E-cadherin expression, while increasing that of N-cadherin, vimentin, and inhibitor of differentiation 1 proteins that are associated with the epithelial-mesenchymal transition. Cell invasion was enhanced through activation of matrix metalloproteinase-9. Conclusion: These results indicate that hormone therapy used in breast cancer may also be effective for ER-positive SAC.

Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalCancer Genomics and Proteomics
Volume13
Issue number4
Publication statusPublished - Jul 1 2016

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cancer Research

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