Stimulatory effects of bacitracin on sporulation and mycelial growth in thiostrepton-producing Streptomyces cyaneus ATCC 14921 and Streptomyces laurentii ATCC 31255

Adel K. Okba, Takahiro Ogata, Hitoshi Matsubara, Yuka Tawara, Ali Abou-Shousha, Shorin Matsuo, Katsumi Doi, Seiya Ogata

Research output: Contribution to journalArticle

Abstract

In a screening program for substances with morphogenic effects on the thiostrepton-producing Streptomyces cyaneus subsp. azureus and S. laurentii, bacitracin (BC) was found to have a remarkable growth-stimulating effect. The stimulatory effect on spore formation was so significant with about 5-fold increment in the number of spores and with striking elongation of the aerial mycelia in S. c. azureus and S. laurentii at 50 and 80 μg/ml, respectively. Also, BC markedly stimulated submerged mycelial growth after a long inhibitory lag period, accompanied by an increase in wet mass of the both species. These peculiar activities of BC on both streptomycetes were compared with its well-known biological and chemical activities. We speculated that the BC-induced stimulation of growth and sporulation might be due to its chelating and antimicrobial activities.

Original languageEnglish
Pages (from-to)461-472
Number of pages12
JournalJournal of the Faculty of Agriculture, Kyushu University
Volume43
Issue number3-4
Publication statusPublished - Feb 1 1999

Fingerprint

Streptomyces laurentii
Streptomyces cyaneus
thiostrepton
Thiostrepton
Bacitracin
bacitracin
Streptomyces
sporulation
Growth
Spores
spores
Mycelium
mycelium
anti-infective agents
screening

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Agronomy and Crop Science

Cite this

Stimulatory effects of bacitracin on sporulation and mycelial growth in thiostrepton-producing Streptomyces cyaneus ATCC 14921 and Streptomyces laurentii ATCC 31255. / Okba, Adel K.; Ogata, Takahiro; Matsubara, Hitoshi; Tawara, Yuka; Abou-Shousha, Ali; Matsuo, Shorin; Doi, Katsumi; Ogata, Seiya.

In: Journal of the Faculty of Agriculture, Kyushu University, Vol. 43, No. 3-4, 01.02.1999, p. 461-472.

Research output: Contribution to journalArticle

Okba, Adel K. ; Ogata, Takahiro ; Matsubara, Hitoshi ; Tawara, Yuka ; Abou-Shousha, Ali ; Matsuo, Shorin ; Doi, Katsumi ; Ogata, Seiya. / Stimulatory effects of bacitracin on sporulation and mycelial growth in thiostrepton-producing Streptomyces cyaneus ATCC 14921 and Streptomyces laurentii ATCC 31255. In: Journal of the Faculty of Agriculture, Kyushu University. 1999 ; Vol. 43, No. 3-4. pp. 461-472.
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AU - Matsubara, Hitoshi

AU - Tawara, Yuka

AU - Abou-Shousha, Ali

AU - Matsuo, Shorin

AU - Doi, Katsumi

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