Stimulatory effects of bacitracin on sporulation and mycelial growth in thiostrepton-producing Streptomyces cyaneus ATCC 14921 and Streptomyces laurentii ATCC 31255

Adel K. Okba, Takahiro Ogata, Hitoshi Matsubara, Yuka Tawara, Ali Abou-Shousha, Shorin Matsuo, Katsumi Doi, Seiya Ogata

Research output: Contribution to journalArticlepeer-review

Abstract

In a screening program for substances with morphogenic effects on the thiostrepton-producing Streptomyces cyaneus subsp. azureus and S. laurentii, bacitracin (BC) was found to have a remarkable growth-stimulating effect. The stimulatory effect on spore formation was so significant with about 5-fold increment in the number of spores and with striking elongation of the aerial mycelia in S. c. azureus and S. laurentii at 50 and 80 μg/ml, respectively. Also, BC markedly stimulated submerged mycelial growth after a long inhibitory lag period, accompanied by an increase in wet mass of the both species. These peculiar activities of BC on both streptomycetes were compared with its well-known biological and chemical activities. We speculated that the BC-induced stimulation of growth and sporulation might be due to its chelating and antimicrobial activities.

Original languageEnglish
Pages (from-to)461-472
Number of pages12
JournalJournal of the Faculty of Agriculture, Kyushu University
Volume43
Issue number3-4
Publication statusPublished - Feb 1 1999

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Agronomy and Crop Science

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