Stimuli-responsive liposome aggregation induced by DNA-surfactants

Tatsuo Maruyama, Mai Hiraki, Hiroshi Yamamura, Harumi Takata, Masahiro Goto

    Research output: Contribution to conferencePaperpeer-review

    Abstract

    Here we describe a novel strategy of liposome aggregation employing DNA-surfactant, in which the aggregation of liposomes can be reversibly controlled by enzyme stimuli and temperature. Single-stranded oligonucleotides (24-mer) were bound to oleic acid to produce DNA-surfactant. The DNA surfactant was mixed with POPC liposomes to prepare DNA-tethered liposomes. Mixing of the DNA-tagged liposomes with ones bearing complementary DNA strands starts the aggregation of liposomes. The liposomes were linked with each other via duplex DNA. We found that the liposome aggregation was influenced by temperature, salt concentration and restriction enzyme.

    Original languageEnglish
    Pages3873-3874
    Number of pages2
    Publication statusPublished - 2005
    Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
    Duration: Sep 20 2005Sep 22 2005

    Other

    Other54th SPSJ Symposium on Macromolecules
    Country/TerritoryJapan
    CityYamagata
    Period9/20/059/22/05

    All Science Journal Classification (ASJC) codes

    • Engineering(all)

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