Abstract
Background: We previously reported that the strain rate dispersion index (SRDI), an index of left ventricular (LV) contractility loss because of mechanical dyssynchrony, better predicted the acute response to cardiac resynchronization therapy (CRT) than time-delay indices. However, it remains unclear whether the SRDI can predict the chronic response. Additionally, the SRDI needs to be simplified for use in clinical practice. Methods and Results: Echocardiography was performed in 40 heart failure patients who underwent CRT. The SRDI, the average of segmental peak systolic strain rates minus global peak systolic strain rate, was calculated, together with strain-derived time-delay indices (St-SD) in the longitudinal, circumferential and radial directions using a speckle-tracking method. As simplified indices, the longitudinal parameters were calculated from the apical 4-chamber view in addition to 3 apical views. LV end-systolic volume (ESV) significantly decreased 6 months after CRT. Although circumferential St-SD and all SRDIs correlated with the changes in ESV (ΔESV), multivariate analysis revealed that the circumferential SRDI was the single independent determinant of ΔESV. During the 20±14 months after CRT, cardiac events occurred in 14 patients. Kaplan-Meier analyses revealed that all SRDIs were significant predictors of cardiac events whereas none of St-SDs was. Conclusions: The SRDI predicted the reduction in both LV volume and cardiac events after CRT better than timedelay indices. Additionally, a simplified SRDI could be as good a predictor of CRT response as the original.
| Original language | English |
|---|---|
| Pages (from-to) | 2757-2765 |
| Number of pages | 9 |
| Journal | Circulation Journal |
| Volume | 77 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Oct 31 2013 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
Strain rate dispersion index can predict changes in left ventricular volume and adverse cardiac events following cardiac resynchronization therapy. / Iwano, Hiroyuki; Yamada, Satoshi; Watanabe, Masaya; Mitsuyama, Hirofumi; Mizukami, Kazuya; Nishino, Hisao; Yokoyama, Shinobu; Kaga, Sanae; Okada, Kazunori; Nishida, Mutsumi; Yokoshiki, Hisashi; Mikami, Taisei; Tsutsui, Hiroyuki.
In: Circulation Journal, Vol. 77, No. 11, 31.10.2013, p. 2757-2765.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Strain rate dispersion index can predict changes in left ventricular volume and adverse cardiac events following cardiac resynchronization therapy
AU - Iwano, Hiroyuki
AU - Yamada, Satoshi
AU - Watanabe, Masaya
AU - Mitsuyama, Hirofumi
AU - Mizukami, Kazuya
AU - Nishino, Hisao
AU - Yokoyama, Shinobu
AU - Kaga, Sanae
AU - Okada, Kazunori
AU - Nishida, Mutsumi
AU - Yokoshiki, Hisashi
AU - Mikami, Taisei
AU - Tsutsui, Hiroyuki
PY - 2013/10/31
Y1 - 2013/10/31
N2 - Background: We previously reported that the strain rate dispersion index (SRDI), an index of left ventricular (LV) contractility loss because of mechanical dyssynchrony, better predicted the acute response to cardiac resynchronization therapy (CRT) than time-delay indices. However, it remains unclear whether the SRDI can predict the chronic response. Additionally, the SRDI needs to be simplified for use in clinical practice. Methods and Results: Echocardiography was performed in 40 heart failure patients who underwent CRT. The SRDI, the average of segmental peak systolic strain rates minus global peak systolic strain rate, was calculated, together with strain-derived time-delay indices (St-SD) in the longitudinal, circumferential and radial directions using a speckle-tracking method. As simplified indices, the longitudinal parameters were calculated from the apical 4-chamber view in addition to 3 apical views. LV end-systolic volume (ESV) significantly decreased 6 months after CRT. Although circumferential St-SD and all SRDIs correlated with the changes in ESV (ΔESV), multivariate analysis revealed that the circumferential SRDI was the single independent determinant of ΔESV. During the 20±14 months after CRT, cardiac events occurred in 14 patients. Kaplan-Meier analyses revealed that all SRDIs were significant predictors of cardiac events whereas none of St-SDs was. Conclusions: The SRDI predicted the reduction in both LV volume and cardiac events after CRT better than timedelay indices. Additionally, a simplified SRDI could be as good a predictor of CRT response as the original.
AB - Background: We previously reported that the strain rate dispersion index (SRDI), an index of left ventricular (LV) contractility loss because of mechanical dyssynchrony, better predicted the acute response to cardiac resynchronization therapy (CRT) than time-delay indices. However, it remains unclear whether the SRDI can predict the chronic response. Additionally, the SRDI needs to be simplified for use in clinical practice. Methods and Results: Echocardiography was performed in 40 heart failure patients who underwent CRT. The SRDI, the average of segmental peak systolic strain rates minus global peak systolic strain rate, was calculated, together with strain-derived time-delay indices (St-SD) in the longitudinal, circumferential and radial directions using a speckle-tracking method. As simplified indices, the longitudinal parameters were calculated from the apical 4-chamber view in addition to 3 apical views. LV end-systolic volume (ESV) significantly decreased 6 months after CRT. Although circumferential St-SD and all SRDIs correlated with the changes in ESV (ΔESV), multivariate analysis revealed that the circumferential SRDI was the single independent determinant of ΔESV. During the 20±14 months after CRT, cardiac events occurred in 14 patients. Kaplan-Meier analyses revealed that all SRDIs were significant predictors of cardiac events whereas none of St-SDs was. Conclusions: The SRDI predicted the reduction in both LV volume and cardiac events after CRT better than timedelay indices. Additionally, a simplified SRDI could be as good a predictor of CRT response as the original.
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U2 - 10.1253/circj.CJ-13-0483
DO - 10.1253/circj.CJ-13-0483
M3 - Article
C2 - 23924889
AN - SCOPUS:84886513766
VL - 77
SP - 2757
EP - 2765
JO - Circulation Journal
JF - Circulation Journal
SN - 1346-9843
IS - 11
ER -