Strategies for treating liver metastasis from gastric cancer

Yoshihiro Kakeji, Masaru Morita, Yoshihiko Maehara

Research output: Contribution to journalReview articlepeer-review

48 Citations (Scopus)

Abstract

The prognosis of patients with liver metastasis from gastric cancer is dismal. This article reviews the characteristics of gastric cancer metastasizing to the liver, and multimodality of treatments. Differentiated adenocarcinoma, poorly differentiated adenocarcinoma with a medullary growth pattern, and special types, including endocrine carcinoma and hepatoid carcinoma, are likely to metastasize to the liver. The overexpression of growth factors or adhesion molecules is clinically signifi cant for liver metastasis. Surgery for liver metastases arising from gastric adenocarcinoma is reasonable if a complete resection seems feasible after careful preoperative staging. A hepatic resection should always be considered as an option for gastric cancer patients with hepatic metastases. Newer generation cytotoxic agents such as S-1, irinotecan, and taxanes show promising activity for patients with metastases. Adjuvant chemotherapy or molecular targeted therapy will provide signifi cant benefits to patients in the future.

Original languageEnglish
Pages (from-to)287-294
Number of pages8
JournalSurgery today
Volume40
Issue number4
DOIs
Publication statusPublished - Apr 2010

All Science Journal Classification (ASJC) codes

  • Surgery

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