@article{2e053d8828c74670b4ece0c3b217d5e8,
title = "Strategy for Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homocoupling Dimer",
abstract = "A new strategy, a transient homocoupling dimer strategy, for direct catalytic oxidative cross-enolate coupling reactions is developed. Cross-enolate coupling products bearing a (contiguous) tetrasubstituted carbon center were obtained chemoselectively without the need for stoichiometric amounts of strong bases/metal oxidants, and thus, the present catalysis provides a general method for the synthesis of unnatural α,α-disubstituted amino acid motifs. The distinct transformation of azlactone and 2-acylimidazole units highlighted the synthetic utility of the present catalysis.",
author = "Takafumi Tanaka and Tsukushi Tanaka and Taro Tsuji and Ryo Yazaki and Takashi Ohshima",
note = "Funding Information: This work was financially supported by JSPS KAKENHI Grant Number JP15H05846 in Middle Molecular Strategy, JP16H01032 in Precisely Designed Catalysts with Customized Scaffolding, Grant-in-Aid for Scientific Research (C) (#16K08166), and Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED under Grant Number JP17am0101091. R.Y. thanks Yoshida Foundation for Promotion of Learning and Education and the Tokyo Biochemical Research Foundation. Funding Information: This work was financially supported by JSPS KAKENHI Grant Number JP15H05846 in Middle Molecular Strategy, JP16H01032 in Precisely Designed Catalysts with Customized Scaffolding, Grant-in-Aid for Scientific Research (C) (#16K08166), and Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED under Grant Number JP17am0101091. R.Y. thanks Yoshida Foundation for Promotion of Learning and Education and the Tokyo Biochemical Research Foundation. We thank Dr. Kazuteru Usui and Rikiya Horikawa at Kyushu University for assistance with X-ray crystallography. Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",
year = "2018",
month = jun,
day = "15",
doi = "10.1021/acs.orglett.8b01313",
language = "English",
volume = "20",
pages = "3541--3544",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "12",
}