TY - JOUR
T1 - Streptozotocin, an inducer of NAD+ decrease, attenuates M-potassium current inhibition by ATP, bradykinin, angiotensin II, endothelin 1 and acetylcholine in NG108-15 cells
AU - Higashida, Haruhiro
AU - Egorova, Alla
AU - Hoshi, Naoto
AU - Noda, Mami
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1996/2/5
Y1 - 1996/2/5
N2 - The M-potassium current was inhibited by bath application of 100 μM ATP, 10 nM bradykinin, 100 nM angiotensin II and 100 nM endothelin 1 as well as by 10 μM acetylcholine in an m1-muscarinic acetylcholine receptor-transformed NG108-15 cell line. The inhibition of M-current was attenuated in cells pretreated with 5 mM streptozotocin for 5-15 h and restored by simultaneous incubation with 5 mM nicotinamide. The results suggest that signal transduction from these five different receptors to M channels shares a common pathway which is susceptible to a streptozotocin-induced decrease in cellular NAD+ content.
AB - The M-potassium current was inhibited by bath application of 100 μM ATP, 10 nM bradykinin, 100 nM angiotensin II and 100 nM endothelin 1 as well as by 10 μM acetylcholine in an m1-muscarinic acetylcholine receptor-transformed NG108-15 cell line. The inhibition of M-current was attenuated in cells pretreated with 5 mM streptozotocin for 5-15 h and restored by simultaneous incubation with 5 mM nicotinamide. The results suggest that signal transduction from these five different receptors to M channels shares a common pathway which is susceptible to a streptozotocin-induced decrease in cellular NAD+ content.
UR - http://www.scopus.com/inward/record.url?scp=0030061129&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030061129&partnerID=8YFLogxK
U2 - 10.1016/0014-5793(95)01516-7
DO - 10.1016/0014-5793(95)01516-7
M3 - Article
C2 - 8603696
AN - SCOPUS:0030061129
VL - 379
SP - 236
EP - 238
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 3
ER -