Streptozotocin, an inducer of NAD+ decrease, attenuates M-potassium current inhibition by ATP, bradykinin, angiotensin II, endothelin 1 and acetylcholine in NG108-15 cells

Haruhiro Higashida, Alla Egorova, Naoto Hoshi, Mami Noda

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The M-potassium current was inhibited by bath application of 100 μM ATP, 10 nM bradykinin, 100 nM angiotensin II and 100 nM endothelin 1 as well as by 10 μM acetylcholine in an m1-muscarinic acetylcholine receptor-transformed NG108-15 cell line. The inhibition of M-current was attenuated in cells pretreated with 5 mM streptozotocin for 5-15 h and restored by simultaneous incubation with 5 mM nicotinamide. The results suggest that signal transduction from these five different receptors to M channels shares a common pathway which is susceptible to a streptozotocin-induced decrease in cellular NAD+ content.

Original languageEnglish
Pages (from-to)236-238
Number of pages3
JournalFEBS Letters
Volume379
Issue number3
DOIs
Publication statusPublished - Feb 5 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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