Stroke during pregnancy and puerperium among Japanese women: a single-center registry

Shinji Katsuragi, Rieko Suzuki, Kazunori Toyoda, Reiko Neki, Susumu Miyamoto, Koji Iihara, Jun Takahashi, Tomoaki Ikeda, Jun Yoshimatsu

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Abstract

Background: Stroke is one of the major causes of maternal death. This study aimed to analyze the maternal and fetal outcomes of stroke occurred during pregnancy and puerperium. Methods: We conducted a retrospective analysis of patients admitted to our perinatology center between 1982 and 2012 with a diagnosis of acute cerebral stroke during pregnancy or within 6 weeks postpartum. Results: Thirty-four patients were registered and all the patients had never been diagnosed as stroke nor detected cerebrovascular abnormalities before the current pregnancies. They were divided into 8 ischemic strokes (ISs) and 26 intracranial hemorrhage group. In the hemorrhage group, there was a spontaneous abortion and two patients chose artificial abortions to avoid rehemorrhage, and there were another three intrauterine fetal deaths (IUFDs) in the acute stage of maternal stroke. More patients in hemorrhage group delivered in preterm than in IS group for the treatment of stroke, 10/23 (43%) versus 0/8 (0%), p <.05. More patients in hemorrhage group had low Glasgow Coma Scale (GCS) (3–8) than in IS group at the onset of the stroke, 12/26 (46%) versus 0/8 (0%), p <.05. There were three maternal deaths and 6/23 (26%) were neurologically dependent in hemorrhage group in the chronic stage, whereas 87% were independent in IS group, p <.05. Conclusions: Hemorrhagic stroke was more common etiology of stroke related to pregnancy than IS in this study. Intensive and multidisciplinary care was needed especially in hemorrhagic stroke related to pregnancy as in the hemorrhagic stroke the fetal survival rate was lower, and maternal conscious levels at the onset of the stroke and neurological outcomes in the chronic stage were worse than IS.

Original languageEnglish
JournalJournal of Maternal-Fetal and Neonatal Medicine
DOIs
Publication statusAccepted/In press - Jan 1 2019

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All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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Katsuragi, S., Suzuki, R., Toyoda, K., Neki, R., Miyamoto, S., Iihara, K., ... Yoshimatsu, J. (Accepted/In press). Stroke during pregnancy and puerperium among Japanese women: a single-center registry. Journal of Maternal-Fetal and Neonatal Medicine. https://doi.org/10.1080/14767058.2019.1675626