Stroke in a child safely treated with intravenous tissue plasminogen activator and edaravone, a free radical scavenger

Haruhisa Baba, Hiroshi Sugimori, Etsuro Nanishi, Hazumu Nagata, Sooyoung Lee, Takahiro Kuwashiro, Makoto Hashizume

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

An 11-year-old female felt discomfort in her head, and left hemispheric syndrome occurred shortly thereafter. At presentation, her National Institutes of Health stroke scale (NIHSS) score was 13, and a magnetic resonance imaging scan revealed acute brain infarction in the left thalamus. She was immediately treated with the intravenous administration of tissue plasminogen activator (IV t-PA) followed by edaravone, a free radical scavenger. Two hours after IV t-PA, her symptoms dramatically resolved and her NIHSS score decreased to 5. No adverse events were observed. She was the youngest patient treated with IV t-PA in Japan, and would be the youngest treated in most developed countries. An optimal treatment for stroke in children has not been established, and this case highlights the urgent need to examine the safety and efficacy of IV t-PA and edaravone therapy for ischemic stroke in children.

Original languageEnglish
Pages (from-to)903.e5-903.e8
JournalJournal of Stroke and Cerebrovascular Diseases
Volume21
Issue number8
DOIs
Publication statusPublished - Jan 1 2012

Fingerprint

Free Radical Scavengers
Tissue Plasminogen Activator
Intravenous Administration
Stroke
National Institutes of Health (U.S.)
Brain Infarction
Thalamus
Developed Countries
Japan
Head
Magnetic Resonance Imaging
Safety
phenylmethylpyrazolone
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Stroke in a child safely treated with intravenous tissue plasminogen activator and edaravone, a free radical scavenger. / Baba, Haruhisa; Sugimori, Hiroshi; Nanishi, Etsuro; Nagata, Hazumu; Lee, Sooyoung; Kuwashiro, Takahiro; Hashizume, Makoto.

In: Journal of Stroke and Cerebrovascular Diseases, Vol. 21, No. 8, 01.01.2012, p. 903.e5-903.e8.

Research output: Contribution to journalArticle

Baba, Haruhisa ; Sugimori, Hiroshi ; Nanishi, Etsuro ; Nagata, Hazumu ; Lee, Sooyoung ; Kuwashiro, Takahiro ; Hashizume, Makoto. / Stroke in a child safely treated with intravenous tissue plasminogen activator and edaravone, a free radical scavenger. In: Journal of Stroke and Cerebrovascular Diseases. 2012 ; Vol. 21, No. 8. pp. 903.e5-903.e8.
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