Abstract
An 11-year-old female felt discomfort in her head, and left hemispheric syndrome occurred shortly thereafter. At presentation, her National Institutes of Health stroke scale (NIHSS) score was 13, and a magnetic resonance imaging scan revealed acute brain infarction in the left thalamus. She was immediately treated with the intravenous administration of tissue plasminogen activator (IV t-PA) followed by edaravone, a free radical scavenger. Two hours after IV t-PA, her symptoms dramatically resolved and her NIHSS score decreased to 5. No adverse events were observed. She was the youngest patient treated with IV t-PA in Japan, and would be the youngest treated in most developed countries. An optimal treatment for stroke in children has not been established, and this case highlights the urgent need to examine the safety and efficacy of IV t-PA and edaravone therapy for ischemic stroke in children.
| Original language | English |
|---|---|
| Pages (from-to) | 903.e5-903.e8 |
| Journal | Journal of Stroke and Cerebrovascular Diseases |
| Volume | 21 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Jan 1 2012 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Rehabilitation
- Clinical Neurology
- Cardiology and Cardiovascular Medicine
Cite this
Stroke in a child safely treated with intravenous tissue plasminogen activator and edaravone, a free radical scavenger. / Baba, Haruhisa; Sugimori, Hiroshi; Nanishi, Etsuro; Nagata, Hazumu; Lee, Sooyoung; Kuwashiro, Takahiro; Hashizume, Makoto.
In: Journal of Stroke and Cerebrovascular Diseases, Vol. 21, No. 8, 01.01.2012, p. 903.e5-903.e8.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Stroke in a child safely treated with intravenous tissue plasminogen activator and edaravone, a free radical scavenger
AU - Baba, Haruhisa
AU - Sugimori, Hiroshi
AU - Nanishi, Etsuro
AU - Nagata, Hazumu
AU - Lee, Sooyoung
AU - Kuwashiro, Takahiro
AU - Hashizume, Makoto
PY - 2012/1/1
Y1 - 2012/1/1
N2 - An 11-year-old female felt discomfort in her head, and left hemispheric syndrome occurred shortly thereafter. At presentation, her National Institutes of Health stroke scale (NIHSS) score was 13, and a magnetic resonance imaging scan revealed acute brain infarction in the left thalamus. She was immediately treated with the intravenous administration of tissue plasminogen activator (IV t-PA) followed by edaravone, a free radical scavenger. Two hours after IV t-PA, her symptoms dramatically resolved and her NIHSS score decreased to 5. No adverse events were observed. She was the youngest patient treated with IV t-PA in Japan, and would be the youngest treated in most developed countries. An optimal treatment for stroke in children has not been established, and this case highlights the urgent need to examine the safety and efficacy of IV t-PA and edaravone therapy for ischemic stroke in children.
AB - An 11-year-old female felt discomfort in her head, and left hemispheric syndrome occurred shortly thereafter. At presentation, her National Institutes of Health stroke scale (NIHSS) score was 13, and a magnetic resonance imaging scan revealed acute brain infarction in the left thalamus. She was immediately treated with the intravenous administration of tissue plasminogen activator (IV t-PA) followed by edaravone, a free radical scavenger. Two hours after IV t-PA, her symptoms dramatically resolved and her NIHSS score decreased to 5. No adverse events were observed. She was the youngest patient treated with IV t-PA in Japan, and would be the youngest treated in most developed countries. An optimal treatment for stroke in children has not been established, and this case highlights the urgent need to examine the safety and efficacy of IV t-PA and edaravone therapy for ischemic stroke in children.
UR - http://www.scopus.com/inward/record.url?scp=84868377813&partnerID=8YFLogxK
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U2 - 10.1016/j.jstrokecerebrovasdis.2011.02.010
DO - 10.1016/j.jstrokecerebrovasdis.2011.02.010
M3 - Article
C2 - 21421331
AN - SCOPUS:84868377813
VL - 21
SP - 903.e5-903.e8
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
SN - 1052-3057
IS - 8
ER -