Strong antihyperglycemic effects of water-soluble fraction of Brazilian propolis and its bioactive constituent, 3,4,5-tri-O-caffeoylquinic acid

Toshiro Matsui, Sumi Ebuchi, Tomoko Fujise, Kanthi J.M. Abesundara, Shima Doi, Hideo Yamada, Kiyoshi Matsumoto

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

To clarify the suppression of postprandial blood glucose rise via α-glucosidase (AGH) inhibitory action by natural compounds, propolis was examined in this study. A single oral administration of propolis extract (50% methanol fraction on XAD-2 column chromatography) in Sprague-Dawley rats demonstrated a potent antihyperglycemic effect with the significant AUC 0-120 min reduction of 38% at a dose of 20 mg/kg compared to that of controls. Among the active compounds isolated from the fraction, 3,4,5-tri-caffeoylquinic acid was found to be a prominent candidate that exerts the effect and shows a strong maltase-specific inhibition with an IC 50 value of 24 μM. In addition, the noncompetitive inhibition power apparently increased with the number of caffeoyl groups bound to quinic acid.

Original languageEnglish
Pages (from-to)1797-1803
Number of pages7
JournalBiological and Pharmaceutical Bulletin
Volume27
Issue number11
DOIs
Publication statusPublished - Nov 1 2004

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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