Structural analysis by NMR of antitumor drug-DNA complexes

9-aminoanthracycline (SM-5887)

Junetsu Igarashi, Makoto Sunagawa

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

SM-5887 is an anthracycline antibiotic with a potent antitumor activity and low toxicity. The structure of the 2:1 SM-5887 -d(CGTACG) complex has been studied in solution by 2D NMR spectroscopy. These data revealed that SM-5887 intercalated between the cytosine and guanine residues and the sugar moiety lay in the minor groove. The intercalation geometry of SM-5887 was a hybrid between those of adriamycin and nogalamycin.

Original languageEnglish
Pages (from-to)2923-2928
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number23
DOIs
Publication statusPublished - Dec 7 1995
Externally publishedYes

Fingerprint

Structural analysis
Antineoplastic Agents
Nuclear magnetic resonance
DNA
Nogalamycin
Anthracyclines
Cytosine
Guanine
Intercalation
Sugars
Doxorubicin
Nuclear magnetic resonance spectroscopy
Toxicity
Magnetic Resonance Spectroscopy
Anti-Bacterial Agents
Geometry
amrubicin

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Structural analysis by NMR of antitumor drug-DNA complexes : 9-aminoanthracycline (SM-5887). / Igarashi, Junetsu; Sunagawa, Makoto.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 5, No. 23, 07.12.1995, p. 2923-2928.

Research output: Contribution to journalArticle

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