Structural analysis by NMR of antitumor drug-DNA complexes: 9-aminoanthracycline (SM-5887)

Jun etsu Igarashi, Makoto Sunagawa

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

SM-5887 is an anthracycline antibiotic with a potent antitumor activity and low toxicity. The structure of the 2:1 SM-5887 -d(CGTACG) complex has been studied in solution by 2D NMR spectroscopy. These data revealed that SM-5887 intercalated between the cytosine and guanine residues and the sugar moiety lay in the minor groove. The intercalation geometry of SM-5887 was a hybrid between those of adriamycin and nogalamycin.

Original languageEnglish
Pages (from-to)2923-2928
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume5
Issue number23
DOIs
Publication statusPublished - Dec 7 1995
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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