Structural and thermodynamic characterization of the self-adhesive properties of human P-cadherin

Shota Kudo; Jose M.M. Caaveiro; T. Miyafusa; Shuichiro Goda; Keisuke Ishii; Tadashi Matsuura; Yukio Sudou; Tatsuhiko Kodama; Takao Hamakubo; Kouhei Tsumoto

doi:10.1039/c2mb25161b

Structural and thermodynamic characterization of the self-adhesive properties of human P-cadherin

Shota Kudo, Jose M.M. Caaveiro, T. Miyafusa, Shuichiro Goda, Keisuke Ishii, Tadashi Matsuura, Yukio Sudou, Tatsuhiko Kodama, Takao Hamakubo, Kouhei Tsumoto

Pharmaceutical Health Care and Sciences

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Human P-cadherin is a promising therapeutic target against cancer. However, its characterization at the molecular level is still lacking. We report that human P-cadherin associated irreversibly in a distinct dimer configuration. Unexpectedly, the divalent cation Ca2+ was not necessary for dimerization, although it greatly stabilized the protein–protein complex.

Original language	English
Pages (from-to)	2050-2053
Number of pages	4
Journal	Molecular BioSystems
Volume	8
DOIs	https://doi.org/10.1039/c2mb25161b
Publication status	Published - 2012

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10.1039/c2mb25161b

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Structural and thermodynamic characterization of the self-adhesive properties of human P-cadherin. / Kudo, Shota; Caaveiro, Jose M.M.; Miyafusa, T.; Goda, Shuichiro; Ishii, Keisuke; Matsuura, Tadashi; Sudou, Yukio; Kodama, Tatsuhiko; Hamakubo, Takao; Tsumoto, Kouhei.

In: Molecular BioSystems, Vol. 8, 2012, p. 2050-2053.

Research output: Contribution to journal › Article › peer-review

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AU - Caaveiro, Jose M.M.

AU - Miyafusa, T.

AU - Goda, Shuichiro

AU - Ishii, Keisuke

AU - Matsuura, Tadashi

AU - Sudou, Yukio

AU - Kodama, Tatsuhiko

AU - Hamakubo, Takao

AU - Tsumoto, Kouhei

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AB - Human P-cadherin is a promising therapeutic target against cancer. However, its characterization at the molecular level is still lacking. We report that human P-cadherin associated irreversibly in a distinct dimer configuration. Unexpectedly, the divalent cation Ca2+ was not necessary for dimerization, although it greatly stabilized the protein–protein complex.

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DO - 10.1039/c2mb25161b

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JO - Molecular BioSystems

JF - Molecular BioSystems

SN - 1742-206X

ER -

Structural and thermodynamic characterization of the self-adhesive properties of human P-cadherin

Abstract

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