Abstract
Human P-cadherin is a promising therapeutic target against cancer. However, its characterization at the molecular level is still lacking. We report that human P-cadherin associated irreversibly in a distinct dimer configuration. Unexpectedly, the divalent cation Ca2+ was not necessary for dimerization, although it greatly stabilized the protein–protein complex.
Original language | English |
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Pages (from-to) | 2050-2053 |
Number of pages | 4 |
Journal | Molecular BioSystems |
Volume | 8 |
DOIs | |
Publication status | Published - 2012 |