Structural and thermodynamic characterization of the self-adhesive properties of human P-cadherin

Shota Kudo, Jose M.M. Caaveiro, T. Miyafusa, Shuichiro Goda, Keisuke Ishii, Tadashi Matsuura, Yukio Sudou, Tatsuhiko Kodama, Takao Hamakubo, Kouhei Tsumoto

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7 Citations (Scopus)

Abstract

Human P-cadherin is a promising therapeutic target against cancer. However, its characterization at the molecular level is still lacking. We report that human P-cadherin associated irreversibly in a distinct dimer configuration. Unexpectedly, the divalent cation Ca2+ was not necessary for dimerization, although it greatly stabilized the protein–protein complex.
Original languageEnglish
Pages (from-to)2050-2053
Number of pages4
JournalMolecular BioSystems
Volume8
DOIs
Publication statusPublished - 2012

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Cadherins
Thermodynamics
Adhesives
Divalent Cations
Dimerization
Neoplasms
Therapeutics

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Structural and thermodynamic characterization of the self-adhesive properties of human P-cadherin. / Kudo, Shota; Caaveiro, Jose M.M.; Miyafusa, T.; Goda, Shuichiro; Ishii, Keisuke; Matsuura, Tadashi; Sudou, Yukio; Kodama, Tatsuhiko; Hamakubo, Takao; Tsumoto, Kouhei.

In: Molecular BioSystems, Vol. 8, 2012, p. 2050-2053.

Research output: Contribution to journalArticle

Kudo, S, Caaveiro, JMM, Miyafusa, T, Goda, S, Ishii, K, Matsuura, T, Sudou, Y, Kodama, T, Hamakubo, T & Tsumoto, K 2012, 'Structural and thermodynamic characterization of the self-adhesive properties of human P-cadherin', Molecular BioSystems, vol. 8, pp. 2050-2053. https://doi.org/10.1039/c2mb25161b
Kudo, Shota ; Caaveiro, Jose M.M. ; Miyafusa, T. ; Goda, Shuichiro ; Ishii, Keisuke ; Matsuura, Tadashi ; Sudou, Yukio ; Kodama, Tatsuhiko ; Hamakubo, Takao ; Tsumoto, Kouhei. / Structural and thermodynamic characterization of the self-adhesive properties of human P-cadherin. In: Molecular BioSystems. 2012 ; Vol. 8. pp. 2050-2053.
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