Structural and thermodynamic characterization of the self-adhesive properties of human P-cadherin

Shota Kudo, Jose M.M. Caaveiro, T. Miyafusa, Shuichiro Goda, Keisuke Ishii, Tadashi Matsuura, Yukio Sudou, Tatsuhiko Kodama, Takao Hamakubo, Kouhei Tsumoto

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Human P-cadherin is a promising therapeutic target against cancer. However, its characterization at the molecular level is still lacking. We report that human P-cadherin associated irreversibly in a distinct dimer configuration. Unexpectedly, the divalent cation Ca2+ was not necessary for dimerization, although it greatly stabilized the protein–protein complex.
Original languageEnglish
Pages (from-to)2050-2053
Number of pages4
JournalMolecular BioSystems
Volume8
DOIs
Publication statusPublished - 2012

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