Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 2050-2053 |
| Number of pages | 4 |
| Journal | Molecular BioSystems |
| Volume | 8 |
| DOIs | |
| Publication status | Published - 2012 |
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Structural and thermodynamic characterization of the self-adhesive properties of human P-cadherin. / Kudo, Shota; Caaveiro, Jose M.M.; Miyafusa, T.; Goda, Shuichiro; Ishii, Keisuke; Matsuura, Tadashi; Sudou, Yukio; Kodama, Tatsuhiko; Hamakubo, Takao; Tsumoto, Kouhei.
In: Molecular BioSystems, Vol. 8, 2012, p. 2050-2053.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Structural and thermodynamic characterization of the self-adhesive properties of human P-cadherin
AU - Kudo, Shota
AU - Caaveiro, Jose M.M.
AU - Miyafusa, T.
AU - Goda, Shuichiro
AU - Ishii, Keisuke
AU - Matsuura, Tadashi
AU - Sudou, Yukio
AU - Kodama, Tatsuhiko
AU - Hamakubo, Takao
AU - Tsumoto, Kouhei
PY - 2012
Y1 - 2012
N2 - Human P-cadherin is a promising therapeutic target against cancer. However, its characterization at the molecular level is still lacking. We report that human P-cadherin associated irreversibly in a distinct dimer configuration. Unexpectedly, the divalent cation Ca2+ was not necessary for dimerization, although it greatly stabilized the protein–protein complex.
AB - Human P-cadherin is a promising therapeutic target against cancer. However, its characterization at the molecular level is still lacking. We report that human P-cadherin associated irreversibly in a distinct dimer configuration. Unexpectedly, the divalent cation Ca2+ was not necessary for dimerization, although it greatly stabilized the protein–protein complex.
U2 - 10.1039/c2mb25161b
DO - 10.1039/c2mb25161b
M3 - Article
C2 - 22673742
VL - 8
SP - 2050
EP - 2053
JO - Molecular BioSystems
JF - Molecular BioSystems
SN - 1742-206X
ER -