[Structural basis for measles virus-receptor recognition and its functional implications for viral entry and vaccination].

Research output: Contribution to journalReview article

Abstract

Measles is one of the most contagious and devastating viral diseases. However, highly effective live vaccines have been successfully used for more than five decades. Recent structural studies of measles virus hemagglutinin and its complexes with receptors (the signaling lymphocyte activation molecule (SLAM, CD150) and CD46) have provided many insights into measles virus entry mechanism. Furthermore, the sugar shields that cover the large surface areas of the hemagglutinin have implications for effective measles virus vaccination. These studies should help strengthen current global efforts to control and eliminate measles worldwide.

Original languageEnglish
Pages (from-to)695-703
Number of pages9
JournalNihon rinsho. Japanese journal of clinical medicine
Volume70
Issue number4
Publication statusPublished - Jan 1 2012

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Virus Receptors
Measles virus
Vaccination
Measles
Hemagglutinins
Virus Internalization
Virus Diseases
Lymphocyte Activation
Vaccines

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "[Structural basis for measles virus-receptor recognition and its functional implications for viral entry and vaccination].",
abstract = "Measles is one of the most contagious and devastating viral diseases. However, highly effective live vaccines have been successfully used for more than five decades. Recent structural studies of measles virus hemagglutinin and its complexes with receptors (the signaling lymphocyte activation molecule (SLAM, CD150) and CD46) have provided many insights into measles virus entry mechanism. Furthermore, the sugar shields that cover the large surface areas of the hemagglutinin have implications for effective measles virus vaccination. These studies should help strengthen current global efforts to control and eliminate measles worldwide.",
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AU - Yanagi, Yusuke

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N2 - Measles is one of the most contagious and devastating viral diseases. However, highly effective live vaccines have been successfully used for more than five decades. Recent structural studies of measles virus hemagglutinin and its complexes with receptors (the signaling lymphocyte activation molecule (SLAM, CD150) and CD46) have provided many insights into measles virus entry mechanism. Furthermore, the sugar shields that cover the large surface areas of the hemagglutinin have implications for effective measles virus vaccination. These studies should help strengthen current global efforts to control and eliminate measles worldwide.

AB - Measles is one of the most contagious and devastating viral diseases. However, highly effective live vaccines have been successfully used for more than five decades. Recent structural studies of measles virus hemagglutinin and its complexes with receptors (the signaling lymphocyte activation molecule (SLAM, CD150) and CD46) have provided many insights into measles virus entry mechanism. Furthermore, the sugar shields that cover the large surface areas of the hemagglutinin have implications for effective measles virus vaccination. These studies should help strengthen current global efforts to control and eliminate measles worldwide.

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