Structural effect of cationic copolymers on nucleic acid-chaperoning activity.

Kaoru Takada, Sung Won Choi, Asako Yamayoshi, Arihiro Kano, Atsushi Maruyama

Research output: Contribution to journalArticle

Abstract

In order to evaluate the effect of cationic copolymer structures on their nucleic acid-chaperoning activity, we prepared various copolymers having different cationic residues or backbone molecular weight. It was revealed that nucleic acid-chaperoning activity increases with increasing molecular weight of the copolymer backbone and that the copolymer having the guanidino groups is effective for increasing nucleic acid-chaperoning activity. Compared with PLL-g-Dex, GPLL-g-Dex has weak activity to stabilize ds DNA. This weak stabilization effect of GPLL-g-Dex may contribute to the higher accelerating effect.

Original languageEnglish
Pages (from-to)27-28
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number50
Publication statusPublished - Jan 1 2006

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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