Structural Elucidation of Minor Components of Peptidyl Antibiotic P168s (Leucinostatins) by Tandem Mass Spectrometry

Akira Isogai; Jiro Nakayama; Seiji Takayama; Akinori Suzuki; Akihiko Kusai

doi:10.1271/bbb.56.1079

Structural Elucidation of Minor Components of Peptidyl Antibiotic P168s (Leucinostatins) by Tandem Mass Spectrometry

Akira Isogai, Jiro Nakayama, Seiji Takayama, Akinori Suzuki, Akihiko Kusai

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Tandem mass spectrometry with a four-sector type mass spectrometer was used to elucidate the structures of minor components of the peptidyl antibiotic P168s (leucinostatins). As N-terminal fragments, ions by B-type cleavage were dominant, while V-type cleavages were observed along with X, Y, and Z types as C-terminal ions. The V-type ions were predominant in the cleavages of the amino terminals of leucyl and hydroxyleucyl residues. The structures of several minor components could be deduced from the tandem mass spectra.

Original language	English
Pages (from-to)	1079-1085
Number of pages	7
Journal	Bioscience, biotechnology, and biochemistry
Volume	56
Issue number	7
DOIs	https://doi.org/10.1271/bbb.56.1079
Publication status	Published - 1992
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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author = "Akira Isogai and Jiro Nakayama and Seiji Takayama and Akinori Suzuki and Akihiko Kusai",

year = "1992",

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AU - Isogai, Akira

AU - Nakayama, Jiro

AU - Takayama, Seiji

AU - Suzuki, Akinori

AU - Kusai, Akihiko

PY - 1992

Y1 - 1992

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AB - Tandem mass spectrometry with a four-sector type mass spectrometer was used to elucidate the structures of minor components of the peptidyl antibiotic P168s (leucinostatins). As N-terminal fragments, ions by B-type cleavage were dominant, while V-type cleavages were observed along with X, Y, and Z types as C-terminal ions. The V-type ions were predominant in the cleavages of the amino terminals of leucyl and hydroxyleucyl residues. The structures of several minor components could be deduced from the tandem mass spectra.

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Structural Elucidation of Minor Components of Peptidyl Antibiotic P168s (Leucinostatins) by Tandem Mass Spectrometry

Abstract

All Science Journal Classification (ASJC) codes

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