Structural factors directing nanosized polyion complex vesicles (Nano-PICsomes) to form a pair of block aniomer/homo catiomers: Studies on the aniomer segment length and the catiomer side-chain structure

Sayan Chuanoi, Akihiro Kishimura, Wen Fei Dong, Yasutaka Anraku, Yuichi Yamasaki, Kazunori Kataoka

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Much attention has been devoted to precise control of the size and morphology in nanosized molecular assemblies for a wide range of materials applications. Recently, we reported observing submicron/nanosized polyion complex vesicles (Nano-PICsomes) with a narrow size distribution, synthesized using specific types of homocatiomers and polyethylene glycol (PEG)-based block aniomers. However, only one example of Nano-PICsomes has been reported to date. Here, the role of the chemical composition of PEG-based block aniomers and the chemical structures of the side chains of homocatiomers were carefully examined to better understand the formation of Nano-PICsomes. Transmission electron microscopy and dynamic light scattering analyses of Nano-PICsomes revealed that a longer length of ionic segments in the block aniomers or a PEG weight fraction (f PEG) <10%, is required for the selective formation of Nano-PICsomes, whereas polymer combinations with f PEG >10% produced spherical micelles. In addition, the homocatiomers containing longer aliphatic side chains (e.g., five or six carbon atoms) favored the formation of Nano-PICsomes, whereas those containing shorter aliphatic side chains produced irregularly shaped PIC micelles. Accordingly, f PEG and the length of the side chain were found to be the key factors that control the morphologies of Nano-PICsomes. Insights gained from this study can broaden the spectrum of the design of Nano-PICsomes for use in a diverse range of material applications.

Original languageEnglish
Pages (from-to)130-135
Number of pages6
JournalPolymer Journal
Volume46
Issue number2
DOIs
Publication statusPublished - Feb 1 2014

Fingerprint

Polyethylene glycols
Micelles
Dynamic light scattering
Carbon
Transmission electron microscopy
Atoms
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Polymers and Plastics
  • Materials Chemistry

Cite this

Structural factors directing nanosized polyion complex vesicles (Nano-PICsomes) to form a pair of block aniomer/homo catiomers : Studies on the aniomer segment length and the catiomer side-chain structure. / Chuanoi, Sayan; Kishimura, Akihiro; Dong, Wen Fei; Anraku, Yasutaka; Yamasaki, Yuichi; Kataoka, Kazunori.

In: Polymer Journal, Vol. 46, No. 2, 01.02.2014, p. 130-135.

Research output: Contribution to journalArticle

@article{463ccde179004fb794dd4feb1149ef2f,
title = "Structural factors directing nanosized polyion complex vesicles (Nano-PICsomes) to form a pair of block aniomer/homo catiomers: Studies on the aniomer segment length and the catiomer side-chain structure",
abstract = "Much attention has been devoted to precise control of the size and morphology in nanosized molecular assemblies for a wide range of materials applications. Recently, we reported observing submicron/nanosized polyion complex vesicles (Nano-PICsomes) with a narrow size distribution, synthesized using specific types of homocatiomers and polyethylene glycol (PEG)-based block aniomers. However, only one example of Nano-PICsomes has been reported to date. Here, the role of the chemical composition of PEG-based block aniomers and the chemical structures of the side chains of homocatiomers were carefully examined to better understand the formation of Nano-PICsomes. Transmission electron microscopy and dynamic light scattering analyses of Nano-PICsomes revealed that a longer length of ionic segments in the block aniomers or a PEG weight fraction (f PEG) <10{\%}, is required for the selective formation of Nano-PICsomes, whereas polymer combinations with f PEG >10{\%} produced spherical micelles. In addition, the homocatiomers containing longer aliphatic side chains (e.g., five or six carbon atoms) favored the formation of Nano-PICsomes, whereas those containing shorter aliphatic side chains produced irregularly shaped PIC micelles. Accordingly, f PEG and the length of the side chain were found to be the key factors that control the morphologies of Nano-PICsomes. Insights gained from this study can broaden the spectrum of the design of Nano-PICsomes for use in a diverse range of material applications.",
author = "Sayan Chuanoi and Akihiro Kishimura and Dong, {Wen Fei} and Yasutaka Anraku and Yuichi Yamasaki and Kazunori Kataoka",
year = "2014",
month = "2",
day = "1",
doi = "10.1038/pj.2013.82",
language = "English",
volume = "46",
pages = "130--135",
journal = "Polymer Journal",
issn = "0032-3896",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - Structural factors directing nanosized polyion complex vesicles (Nano-PICsomes) to form a pair of block aniomer/homo catiomers

T2 - Studies on the aniomer segment length and the catiomer side-chain structure

AU - Chuanoi, Sayan

AU - Kishimura, Akihiro

AU - Dong, Wen Fei

AU - Anraku, Yasutaka

AU - Yamasaki, Yuichi

AU - Kataoka, Kazunori

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Much attention has been devoted to precise control of the size and morphology in nanosized molecular assemblies for a wide range of materials applications. Recently, we reported observing submicron/nanosized polyion complex vesicles (Nano-PICsomes) with a narrow size distribution, synthesized using specific types of homocatiomers and polyethylene glycol (PEG)-based block aniomers. However, only one example of Nano-PICsomes has been reported to date. Here, the role of the chemical composition of PEG-based block aniomers and the chemical structures of the side chains of homocatiomers were carefully examined to better understand the formation of Nano-PICsomes. Transmission electron microscopy and dynamic light scattering analyses of Nano-PICsomes revealed that a longer length of ionic segments in the block aniomers or a PEG weight fraction (f PEG) <10%, is required for the selective formation of Nano-PICsomes, whereas polymer combinations with f PEG >10% produced spherical micelles. In addition, the homocatiomers containing longer aliphatic side chains (e.g., five or six carbon atoms) favored the formation of Nano-PICsomes, whereas those containing shorter aliphatic side chains produced irregularly shaped PIC micelles. Accordingly, f PEG and the length of the side chain were found to be the key factors that control the morphologies of Nano-PICsomes. Insights gained from this study can broaden the spectrum of the design of Nano-PICsomes for use in a diverse range of material applications.

AB - Much attention has been devoted to precise control of the size and morphology in nanosized molecular assemblies for a wide range of materials applications. Recently, we reported observing submicron/nanosized polyion complex vesicles (Nano-PICsomes) with a narrow size distribution, synthesized using specific types of homocatiomers and polyethylene glycol (PEG)-based block aniomers. However, only one example of Nano-PICsomes has been reported to date. Here, the role of the chemical composition of PEG-based block aniomers and the chemical structures of the side chains of homocatiomers were carefully examined to better understand the formation of Nano-PICsomes. Transmission electron microscopy and dynamic light scattering analyses of Nano-PICsomes revealed that a longer length of ionic segments in the block aniomers or a PEG weight fraction (f PEG) <10%, is required for the selective formation of Nano-PICsomes, whereas polymer combinations with f PEG >10% produced spherical micelles. In addition, the homocatiomers containing longer aliphatic side chains (e.g., five or six carbon atoms) favored the formation of Nano-PICsomes, whereas those containing shorter aliphatic side chains produced irregularly shaped PIC micelles. Accordingly, f PEG and the length of the side chain were found to be the key factors that control the morphologies of Nano-PICsomes. Insights gained from this study can broaden the spectrum of the design of Nano-PICsomes for use in a diverse range of material applications.

UR - http://www.scopus.com/inward/record.url?scp=84893810949&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893810949&partnerID=8YFLogxK

U2 - 10.1038/pj.2013.82

DO - 10.1038/pj.2013.82

M3 - Article

AN - SCOPUS:84893810949

VL - 46

SP - 130

EP - 135

JO - Polymer Journal

JF - Polymer Journal

SN - 0032-3896

IS - 2

ER -