Structural features of dinoflagellate toxins underlying biological activity as viewed by NMR

Michio Murata, Nobuaki Matsumori, Keiichi Konoki, Tohru Oishi

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Marine dinoflagellates are a rich source of structurally and biologically intriguing secondary metabolites. Among those, maitotoxin may be one of the best known examples, which is the largest natural product known to date and possesses the most potent toxicity known amongst non-proteinaceous compounds. Structural studies of maitotoxin are reviewed with a particular focus on the configuration and mode of action of this unique toxin. In addition, there are many marine natural products which bind to biomembranes to exert their biological activities. To gain a better understanding of their mode of action, conformation, and bimoleeular interaction occurring in biomembranes are particularly important. Recent results from NMR studies of membrane systems in the authors' group are reviewed briefly.

Original languageEnglish
Pages (from-to)307-319
Number of pages13
JournalBulletin of the Chemical Society of Japan
Volume81
Issue number3
DOIs
Publication statusPublished - Dec 1 2008
Externally publishedYes

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Bioactivity
Biological Products
Nuclear magnetic resonance
Metabolites
Toxicity
Conformations
Membranes
maitotoxin

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Structural features of dinoflagellate toxins underlying biological activity as viewed by NMR. / Murata, Michio; Matsumori, Nobuaki; Konoki, Keiichi; Oishi, Tohru.

In: Bulletin of the Chemical Society of Japan, Vol. 81, No. 3, 01.12.2008, p. 307-319.

Research output: Contribution to journalReview article

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