Structural reevaluations of amphidinol 3, a potent antifungal compound from dinoflagellate

Respati T. Swasono; Mitsunori Kanemoto; Nobuaki Matsumori; Tohru Oishi; Michio Murata

doi:10.3987/COM-10-S(E)86

Structural reevaluations of amphidinol 3, a potent antifungal compound from dinoflagellate

Respati T. Swasono, Mitsunori Kanemoto, Nobuaki Matsumori, Tohru Oishi, Michio Murata

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Among other homologues, amphidinol 3 (AM3) is the most potent antifungal compound isolated from the dinoflagellate Amphidinium klebsii. AM3 undergoes conformational changes in organic solvents while it takes relatively fixed configuration in a membrane model. By using NMR data of peracetyl AM3, we were able to confirm the configuration of C50-C51 of AM3 which remained uncertain in our previous study.

Original language	English
Pages (from-to)	1359-1369
Number of pages	11
Journal	Heterocycles
Volume	82
Issue number	2
DOIs	https://doi.org/10.3987/COM-10-S(E)86
Publication status	Published - Feb 28 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Pharmacology
Organic Chemistry

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abstract = "Among other homologues, amphidinol 3 (AM3) is the most potent antifungal compound isolated from the dinoflagellate Amphidinium klebsii. AM3 undergoes conformational changes in organic solvents while it takes relatively fixed configuration in a membrane model. By using NMR data of peracetyl AM3, we were able to confirm the configuration of C50-C51 of AM3 which remained uncertain in our previous study.",

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AU - Kanemoto, Mitsunori

AU - Matsumori, Nobuaki

AU - Oishi, Tohru

AU - Murata, Michio

PY - 2010/2/28

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AB - Among other homologues, amphidinol 3 (AM3) is the most potent antifungal compound isolated from the dinoflagellate Amphidinium klebsii. AM3 undergoes conformational changes in organic solvents while it takes relatively fixed configuration in a membrane model. By using NMR data of peracetyl AM3, we were able to confirm the configuration of C50-C51 of AM3 which remained uncertain in our previous study.

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Structural reevaluations of amphidinol 3, a potent antifungal compound from dinoflagellate

Abstract

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