Structural reevaluations of amphidinol 3, a potent antifungal compound from dinoflagellate

Respati T. Swasono, Mitsunori Kanemoto, Nobuaki Matsumori, Tohru Oishi, Michio Murata

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Among other homologues, amphidinol 3 (AM3) is the most potent antifungal compound isolated from the dinoflagellate Amphidinium klebsii. AM3 undergoes conformational changes in organic solvents while it takes relatively fixed configuration in a membrane model. By using NMR data of peracetyl AM3, we were able to confirm the configuration of C50-C51 of AM3 which remained uncertain in our previous study.

Original languageEnglish
Pages (from-to)1359-1369
Number of pages11
JournalHeterocycles
Volume82
Issue number2
DOIs
Publication statusPublished - Feb 28 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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