Structure-activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidum

Jie Liu, Kenji Kurashiki, Kuniyoshi Shimizu, Ryuichiro Kondo

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46 Citations (Scopus)


In humans, 5α-reductase is involved in the development of benign prostatic hyperplasia. Triterpenoids isolated from ethanol extracts of Ganoderma lucidum (Fr.) Krast (Ganodermataceae) inhibited 5α-reductase activity. The presence of the C-3 carbonyl group and of the C-26-α,β-unsaturated carbonyl group was characteristic of almost all inhibitors isolated from G. lucidum.

Original languageEnglish
Pages (from-to)8654-8660
Number of pages7
JournalBioorganic and Medicinal Chemistry
Issue number24
Publication statusPublished - Dec 15 2006


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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