Abstract
In order to investigate structure-activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE.
| Original language | English |
|---|---|
| Pages (from-to) | 2737-2740 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 13 |
| Issue number | 16 |
| DOIs | |
| Publication status | Published - Aug 18 2003 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
Cite this
Structure-activity relationships of azasugar-based MMP/ADAM inhibitors. / Moriyama, Hideki; Tsukida, Takahiro; Inoue, Yoshimasa; Kondo, Hirosato; Yoshino, Kohichiro; Nishimura, Shin Ichiro.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 16, 18.08.2003, p. 2737-2740.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Structure-activity relationships of azasugar-based MMP/ADAM inhibitors
AU - Moriyama, Hideki
AU - Tsukida, Takahiro
AU - Inoue, Yoshimasa
AU - Kondo, Hirosato
AU - Yoshino, Kohichiro
AU - Nishimura, Shin Ichiro
PY - 2003/8/18
Y1 - 2003/8/18
N2 - In order to investigate structure-activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE.
AB - In order to investigate structure-activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE.
UR - http://www.scopus.com/inward/record.url?scp=0038149014&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038149014&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(03)00530-4
DO - 10.1016/S0960-894X(03)00530-4
M3 - Article
C2 - 12873504
AN - SCOPUS:0038149014
VL - 13
SP - 2737
EP - 2740
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 16
ER -