TY - JOUR
T1 - Structure-activity relationships of azasugar-based MMP/ADAM inhibitors
AU - Moriyama, Hideki
AU - Tsukida, Takahiro
AU - Inoue, Yoshimasa
AU - Kondo, Hirosato
AU - Yoshino, Kohichiro
AU - Nishimura, Shin Ichiro
N1 - Funding Information:
The present work was supported by a grant for ‘Research and Development on Glycocluster Controlling Biomolecules’ from the New Energy and Industrial Technology Development Organization (NEDO).
PY - 2003/8/18
Y1 - 2003/8/18
N2 - In order to investigate structure-activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE.
AB - In order to investigate structure-activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE.
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U2 - 10.1016/S0960-894X(03)00530-4
DO - 10.1016/S0960-894X(03)00530-4
M3 - Article
C2 - 12873504
AN - SCOPUS:0038149014
VL - 13
SP - 2737
EP - 2740
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 16
ER -