Structure-activity relationships of azasugar-based MMP/ADAM inhibitors

Hideki Moriyama, Takahiro Tsukida, Yoshimasa Inoue, Hirosato Kondo, Kohichiro Yoshino, Shin Ichiro Nishimura

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In order to investigate structure-activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE.

Original languageEnglish
Pages (from-to)2737-2740
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number16
DOIs
Publication statusPublished - Aug 18 2003

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Matrix Metalloproteinase 3
Matrix Metalloproteinase 1
Matrix Metalloproteinase Inhibitors
Metalloproteases
Structure-Activity Relationship
Matrix Metalloproteinases
Derivatives

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Structure-activity relationships of azasugar-based MMP/ADAM inhibitors. / Moriyama, Hideki; Tsukida, Takahiro; Inoue, Yoshimasa; Kondo, Hirosato; Yoshino, Kohichiro; Nishimura, Shin Ichiro.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 16, 18.08.2003, p. 2737-2740.

Research output: Contribution to journalArticle

Moriyama, Hideki ; Tsukida, Takahiro ; Inoue, Yoshimasa ; Kondo, Hirosato ; Yoshino, Kohichiro ; Nishimura, Shin Ichiro. / Structure-activity relationships of azasugar-based MMP/ADAM inhibitors. In: Bioorganic and Medicinal Chemistry Letters. 2003 ; Vol. 13, No. 16. pp. 2737-2740.
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