Structure-activity relationships of azasugar-based MMP/ADAM inhibitors

Hideki Moriyama; Takahiro Tsukida; Yoshimasa Inoue; Hirosato Kondo; Kohichiro Yoshino; Shin Ichiro Nishimura

doi:10.1016/S0960-894X(03)00530-4

Structure-activity relationships of azasugar-based MMP/ADAM inhibitors

Hideki Moriyama, Takahiro Tsukida, Yoshimasa Inoue, Hirosato Kondo, Kohichiro Yoshino, Shin Ichiro Nishimura

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

In order to investigate structure-activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE.

Original language	English
Pages (from-to)	2737-2740
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	13
Issue number	16
DOIs	https://doi.org/10.1016/S0960-894X(03)00530-4
Publication status	Published - Aug 18 2003
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

Access to Document

10.1016/S0960-894X(03)00530-4

Fingerprint Dive into the research topics of 'Structure-activity relationships of azasugar-based MMP/ADAM inhibitors'. Together they form a unique fingerprint.

Cite this

@article{5502b61ee23e45f99cb7df13c0c5e01e,

title = "Structure-activity relationships of azasugar-based MMP/ADAM inhibitors",

abstract = "In order to investigate structure-activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE.",

author = "Hideki Moriyama and Takahiro Tsukida and Yoshimasa Inoue and Hirosato Kondo and Kohichiro Yoshino and Nishimura, {Shin Ichiro}",

year = "2003",

month = aug,

day = "18",

doi = "10.1016/S0960-894X(03)00530-4",

language = "English",

volume = "13",

pages = "2737--2740",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "16",

}

TY - JOUR

T1 - Structure-activity relationships of azasugar-based MMP/ADAM inhibitors

AU - Moriyama, Hideki

AU - Tsukida, Takahiro

AU - Inoue, Yoshimasa

AU - Kondo, Hirosato

AU - Yoshino, Kohichiro

AU - Nishimura, Shin Ichiro

PY - 2003/8/18

Y1 - 2003/8/18

N2 - In order to investigate structure-activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE.

AB - In order to investigate structure-activity relationships of azasugar series toward metalloproteinases, we synthesized and evaluated several azasugar-based compounds. As a result, it was found that 4-phenoxybenzene derivative 3 having 2R,3R,4R,5S-configurations exhibited most potent inhibitory activities against matrix metalloproteinase-1, -3 and -9 and TACE.

UR - http://www.scopus.com/inward/record.url?scp=0038149014&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038149014&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(03)00530-4

DO - 10.1016/S0960-894X(03)00530-4

M3 - Article

C2 - 12873504

AN - SCOPUS:0038149014

VL - 13

SP - 2737

EP - 2740

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 16

ER -