Structure determination of the major component of the starfish ganglioside molecular species LG-2 by tandem mass spectrometry

Ryuichi Higuchi, Shuji Matsumoto, Ryuichi Isobe, Tomofumi Miyamoto

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The biologically active ganglioside molecular species, LG-2, which has been obtained from the starfish Astropecten latespinosus, was completely methylated followed by separation using reversed phase HPLC to give a methylated major component, LG-2M-5, in the pure state. The ceramide moiety of LG-2M-5 was indicated by the positive ion fast atom bombardment tandem mass spectrometry (FABMS/MS) of LG-2M-5. This fact was verified from the measurements of the positive ion FABMS/MS of the permethylates prepared from four known starfish cerebrosides.

Original languageEnglish
Pages (from-to)8961-8968
Number of pages8
JournalTetrahedron
Volume51
Issue number33
DOIs
Publication statusPublished - Aug 14 1995

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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