Structure of a novel multidrug resistance modulator, irciniasulfonic acid, isolated from a marine sponge, Ircinia sp.

Ayako Kawakami, Tomofumi Miyamoto, Ryuichi Higuchi, Takeshi Uchiumi, Michihiko Kuwano, Rob W.M. Van Soest

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Irciniasulfonic acid was obtained from a marine sponge of Ircinia sp. Spectroscopic and chemical analyses revealed its structure consists of three different kinds of acids, i.e. common fatty acids, a novel unsaturated branched C-10 fatty acid and an isethionic acid. Irciniasulfonic acid and deacyl irciniasulfonic acid reverse multidrug resistance in human carcinoma cells caused by overexpression of membrane glycoprotein.

Original languageEnglish
Pages (from-to)3335-3337
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number19
DOIs
Publication statusPublished - May 7 2001

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Porifera
Multiple Drug Resistance
Modulators
Acids
Isethionic Acid
Fatty Acids
Membrane Glycoproteins
Cells
Carcinoma

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Structure of a novel multidrug resistance modulator, irciniasulfonic acid, isolated from a marine sponge, Ircinia sp. / Kawakami, Ayako; Miyamoto, Tomofumi; Higuchi, Ryuichi; Uchiumi, Takeshi; Kuwano, Michihiko; Van Soest, Rob W.M.

In: Tetrahedron Letters, Vol. 42, No. 19, 07.05.2001, p. 3335-3337.

Research output: Contribution to journalArticle

Kawakami, Ayako ; Miyamoto, Tomofumi ; Higuchi, Ryuichi ; Uchiumi, Takeshi ; Kuwano, Michihiko ; Van Soest, Rob W.M. / Structure of a novel multidrug resistance modulator, irciniasulfonic acid, isolated from a marine sponge, Ircinia sp. In: Tetrahedron Letters. 2001 ; Vol. 42, No. 19. pp. 3335-3337.
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