Structure of a novel multidrug resistance modulator, irciniasulfonic acid, isolated from a marine sponge, Ircinia sp.

Ayako Kawakami, Tomofumi Miyamoto, Ryuichi Higuchi, Takeshi Uchiumi, Michihiko Kuwano, Rob W.M. Van Soest

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Irciniasulfonic acid was obtained from a marine sponge of Ircinia sp. Spectroscopic and chemical analyses revealed its structure consists of three different kinds of acids, i.e. common fatty acids, a novel unsaturated branched C-10 fatty acid and an isethionic acid. Irciniasulfonic acid and deacyl irciniasulfonic acid reverse multidrug resistance in human carcinoma cells caused by overexpression of membrane glycoprotein.

Original languageEnglish
Pages (from-to)3335-3337
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number19
DOIs
Publication statusPublished - May 7 2001

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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