Structure of membrane-bound amphidinol 3 in isotropic small bicelles

Toshihiro Houdai, Nobuaki Matsumori, Michio Murata

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

(Chemical Equation Presented) Amphidinol 3 (AM3) exhibits a potent membrane permeabilizing activity by forming pores in biological membranes. We examined the conformation and location of AM3 using Isotropic bicelles, a more natural membrane model than micelles. The results show that AM3 takes turn structures at the two tetrahydropyran rings. Most of the hydrophilic region of the molecule is predominantly present in the surface, while the hydrophobic polyolefin penetrates in the bicelle interior.

Original languageEnglish
Pages (from-to)4191-4194
Number of pages4
JournalOrganic Letters
Volume10
Issue number19
DOIs
Publication statusPublished - Dec 1 2008
Externally publishedYes

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membranes
Membranes
Biological membranes
Micelles
Conformations
micelles
porosity
Molecules
rings
amphidinol 3
molecules
PL 732

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Structure of membrane-bound amphidinol 3 in isotropic small bicelles. / Houdai, Toshihiro; Matsumori, Nobuaki; Murata, Michio.

In: Organic Letters, Vol. 10, No. 19, 01.12.2008, p. 4191-4194.

Research output: Contribution to journalArticle

Houdai, Toshihiro ; Matsumori, Nobuaki ; Murata, Michio. / Structure of membrane-bound amphidinol 3 in isotropic small bicelles. In: Organic Letters. 2008 ; Vol. 10, No. 19. pp. 4191-4194.
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