Structure of membrane-bound amphidinol 3 in isotropic small bicelles

Toshihiro Houdai, Nobuaki Matsumori, Michio Murata

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(Chemical Equation Presented) Amphidinol 3 (AM3) exhibits a potent membrane permeabilizing activity by forming pores in biological membranes. We examined the conformation and location of AM3 using Isotropic bicelles, a more natural membrane model than micelles. The results show that AM3 takes turn structures at the two tetrahydropyran rings. Most of the hydrophilic region of the molecule is predominantly present in the surface, while the hydrophobic polyolefin penetrates in the bicelle interior.

Original languageEnglish
Pages (from-to)4191-4194
Number of pages4
JournalOrganic Letters
Issue number19
Publication statusPublished - Dec 1 2008
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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