Structure of the chromosomal gene for human serum prealbumin

Sasaki Hiroyuki; Yoshioka Naoko; Takagi Yasuyuki; Sakaki Yoshiyuki

doi:10.1016/0378-1119(85)90272-0

Structure of the chromosomal gene for human serum prealbumin

Sasaki Hiroyuki, Yoshioka Naoko, Takagi Yasuyuki, Sakaki Yoshiyuki

Department of Molecular and Structural Biology

Research output: Contribution to journal › Article › peer-review

103 Citations (Scopus)

Abstract

The human prealbumin gene has been cloned and its complete nucleotide sequence determined. The gene has a size of about 6.9 kb and is composed of four exons and three introns. Two Alu family sequences having opposing polarity were found in introns. In the 5'-flanking region, we found two overlapping sequences which have extensive homology to the glucocorticoid-responsive element. Three sequences identical with the enhancer core sequence were identified in introns and the 3' -flanking region. Unusual tandem repeats of a sequence, TTTTG, were also found m the 5'-flanking region and introns.

Original language	English
Pages (from-to)	191-197
Number of pages	7
Journal	Gene
Volume	37
Issue number	1-3
DOIs	https://doi.org/10.1016/0378-1119(85)90272-0
Publication status	Published - 1985

All Science Journal Classification (ASJC) codes

Genetics

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abstract = "The human prealbumin gene has been cloned and its complete nucleotide sequence determined. The gene has a size of about 6.9 kb and is composed of four exons and three introns. Two Alu family sequences having opposing polarity were found in introns. In the 5'-flanking region, we found two overlapping sequences which have extensive homology to the glucocorticoid-responsive element. Three sequences identical with the enhancer core sequence were identified in introns and the 3' -flanking region. Unusual tandem repeats of a sequence, TTTTG, were also found m the 5'-flanking region and introns.",

author = "Sasaki Hiroyuki and Yoshioka Naoko and Takagi Yasuyuki and Sakaki Yoshiyuki",

year = "1985",

doi = "10.1016/0378-1119(85)90272-0",

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AU - Hiroyuki, Sasaki

AU - Naoko, Yoshioka

AU - Yasuyuki, Takagi

AU - Yoshiyuki, Sakaki

PY - 1985

Y1 - 1985

N2 - The human prealbumin gene has been cloned and its complete nucleotide sequence determined. The gene has a size of about 6.9 kb and is composed of four exons and three introns. Two Alu family sequences having opposing polarity were found in introns. In the 5'-flanking region, we found two overlapping sequences which have extensive homology to the glucocorticoid-responsive element. Three sequences identical with the enhancer core sequence were identified in introns and the 3' -flanking region. Unusual tandem repeats of a sequence, TTTTG, were also found m the 5'-flanking region and introns.

AB - The human prealbumin gene has been cloned and its complete nucleotide sequence determined. The gene has a size of about 6.9 kb and is composed of four exons and three introns. Two Alu family sequences having opposing polarity were found in introns. In the 5'-flanking region, we found two overlapping sequences which have extensive homology to the glucocorticoid-responsive element. Three sequences identical with the enhancer core sequence were identified in introns and the 3' -flanking region. Unusual tandem repeats of a sequence, TTTTG, were also found m the 5'-flanking region and introns.

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JO - Gene

JF - Gene

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ER -

Structure of the chromosomal gene for human serum prealbumin

Abstract

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