Studies on DNA dynamics using 2-N-tert-butylaminoxylpurines.

Mariko Aso, John Walter Mirc, Manami Kurita, Noboru Koga, Hiroshi Suemune

Research output: Contribution to journalArticle

Abstract

2-N-tert-Butylaminoxylpurines (1) and (2) were synthesized from 2'-deoxy-6-chloropurine derivative by lithiation strategy. Effects of motion of 1 and 2 on EPR spectra were studied by EPR measurement in sucrose solution at various temperatures. The single stranded and duplexed 15-mers containing 1 showed the clear difference in the EPR spectra to indicate 1 has the potential to accurately study the dynamics of purine residues.

Original languageEnglish
Pages (from-to)163-164
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number51
DOIs
Publication statusPublished - 2007

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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