Studies on olivoretins indicate a requirement for a free hydroxyl group for teleocidin B activity

T. Horiuchi; H. Fujiki; M. Suganuma; H. Hakii; M. Nakayasu; Y. Hitotsuyanagi; N. Aimi; S. Sakai; Y. Endo; K. Shudo

Studies on olivoretins indicate a requirement for a free hydroxyl group for teleocidin B activity

T. Horiuchi, H. Fujiki, M. Suganuma, H. Hakii, M. Nakayasu, Y. Hitotsuyanagi, N. Aimi, S. Sakai, Y. Endo, K. Shudo

Research output: Contribution to journal › Article › peer-review

Abstract

Three olivoretins, A, B and C (isolated from Streptoverticillium olivoreticuli), which are O-methylated teleocidin B isomers, were found to be biologically inactive. A fourth olivoretin, D, which has a free hydroxyl group and is identical to one of the four teleocidin B isomers, teleocidin B-4 (teleocidin B of Hirata) was biologically active. These findings indicate that the free primary hydroxyl group of teleocidin B isomers is necessary for activity. The effect on biological activity of the structural difference between des-O-methyl-olivoretin B (teleocidin B-1) and des-O-methylolivoretin C was also studied.

Original language	English
Pages (from-to)	837-840
Number of pages	4
Journal	Gann, The Japanese Journal of Cancer Research
Volume	75
Issue number	10
Publication status	Published - Dec 1 1984
Externally published	Yes

All Science Journal Classification (ASJC) codes

Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Studies on olivoretins indicate a requirement for a free hydroxyl group for teleocidin B activity",

abstract = "Three olivoretins, A, B and C (isolated from Streptoverticillium olivoreticuli), which are O-methylated teleocidin B isomers, were found to be biologically inactive. A fourth olivoretin, D, which has a free hydroxyl group and is identical to one of the four teleocidin B isomers, teleocidin B-4 (teleocidin B of Hirata) was biologically active. These findings indicate that the free primary hydroxyl group of teleocidin B isomers is necessary for activity. The effect on biological activity of the structural difference between des-O-methyl-olivoretin B (teleocidin B-1) and des-O-methylolivoretin C was also studied.",

author = "T. Horiuchi and H. Fujiki and M. Suganuma and H. Hakii and M. Nakayasu and Y. Hitotsuyanagi and N. Aimi and S. Sakai and Y. Endo and K. Shudo",

year = "1984",

month = dec,

day = "1",

language = "English",

volume = "75",

pages = "837--840",

journal = "Cancer Science",

issn = "1347-9032",

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TY - JOUR

T1 - Studies on olivoretins indicate a requirement for a free hydroxyl group for teleocidin B activity

AU - Horiuchi, T.

AU - Fujiki, H.

AU - Suganuma, M.

AU - Hakii, H.

AU - Nakayasu, M.

AU - Hitotsuyanagi, Y.

AU - Aimi, N.

AU - Sakai, S.

AU - Endo, Y.

AU - Shudo, K.

PY - 1984/12/1

Y1 - 1984/12/1

N2 - Three olivoretins, A, B and C (isolated from Streptoverticillium olivoreticuli), which are O-methylated teleocidin B isomers, were found to be biologically inactive. A fourth olivoretin, D, which has a free hydroxyl group and is identical to one of the four teleocidin B isomers, teleocidin B-4 (teleocidin B of Hirata) was biologically active. These findings indicate that the free primary hydroxyl group of teleocidin B isomers is necessary for activity. The effect on biological activity of the structural difference between des-O-methyl-olivoretin B (teleocidin B-1) and des-O-methylolivoretin C was also studied.

AB - Three olivoretins, A, B and C (isolated from Streptoverticillium olivoreticuli), which are O-methylated teleocidin B isomers, were found to be biologically inactive. A fourth olivoretin, D, which has a free hydroxyl group and is identical to one of the four teleocidin B isomers, teleocidin B-4 (teleocidin B of Hirata) was biologically active. These findings indicate that the free primary hydroxyl group of teleocidin B isomers is necessary for activity. The effect on biological activity of the structural difference between des-O-methyl-olivoretin B (teleocidin B-1) and des-O-methylolivoretin C was also studied.

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M3 - Article

C2 - 6439591

AN - SCOPUS:0021684397

SN - 1347-9032

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EP - 840

JO - Cancer Science

JF - Cancer Science

IS - 10

ER -

Studies on olivoretins indicate a requirement for a free hydroxyl group for teleocidin B activity

Abstract

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UN SDGs

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