Studies on olivoretins indicate a requirement for a free hydroxyl group for teleocidin B activity

T. Horiuchi, H. Fujiki, M. Suganuma, H. Hakii, M. Nakayasu, Y. Hitotsuyanagi, N. Aimi, S. Sakai, Y. Endo, K. Shudo

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Abstract

Three olivoretins, A, B and C (isolated from Streptoverticillium olivoreticuli), which are O-methylated teleocidin B isomers, were found to be biologically inactive. A fourth olivoretin, D, which has a free hydroxyl group and is identical to one of the four teleocidin B isomers, teleocidin B-4 (teleocidin B of Hirata) was biologically active. These findings indicate that the free primary hydroxyl group of teleocidin B isomers is necessary for activity. The effect on biological activity of the structural difference between des-O-methyl-olivoretin B (teleocidin B-1) and des-O-methylolivoretin C was also studied.

Original languageEnglish
Pages (from-to)837-840
Number of pages4
JournalGann, The Japanese Journal of Cancer Research
Volume75
Issue number10
Publication statusPublished - Dec 1 1984
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cancer Research

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    Horiuchi, T., Fujiki, H., Suganuma, M., Hakii, H., Nakayasu, M., Hitotsuyanagi, Y., Aimi, N., Sakai, S., Endo, Y., & Shudo, K. (1984). Studies on olivoretins indicate a requirement for a free hydroxyl group for teleocidin B activity. Gann, The Japanese Journal of Cancer Research, 75(10), 837-840.