Studies on the pathogenesis of subacute thyroiditis

N. Kobayashi, H. Tamai, K. Nagai, S. Matsubayashi, F. Matsuzuka, K. Kuma, H. Goto, H. Uno, Takehiko Sasazuki, S. Nagataki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Despite the fact that subacute thyroiditis (SAT) is a common disease, its pathogenesis is still uncertain. At present, viral infection is simply thought to be a possible pathogenic factor. In Caucasians and Chinese, however, a strong association has recently been found between HLA-Bw35 and SAT. Therefore, genetic factors are also thought to participate in the onset of SAT. In this study we have further attempted to clarify the pathogenesis of this disease in this regard. Protocol: HLA typing for A, B and C loci (class I antigens) was performed on 89 patients with SAT (males: 7, females: 82) aged from 23 to 66 years, and DR and MT loci (class II antigens) were investigated in 55 patients. In 12 patients, viral antibody titers were measured as soon as possible after onset and two weeks later. The viral antibodies evaluated were those of Influenza A and B, Coxsackie A9, B1, B2, B3, B4, B5 and B6, Echo 3, 7, 11 and 12, Parainfluenza 1, 2, 3 and 4, and Adeno 8 virus. The following results were obtained: In class I HLA typing, the frequency of HLA-Bw35 in SAT was 67.4%, which was significantly (p less than 0.0001) higher than that in the control (14.1%). On the other hand, the frequency of Cw1 in SAT (14.6%) was significantly (p less than 0.01) lower than that of the control (32.1%), and that of Cw3 (65.2%) was significantly (p less than 0.01) higher than that of the control (46.5%). In class II HLA typing, the frequency of DRw8 in SAT was 38.2%, which was significantly (p less than 0.05) higher than that of the control (21.9%). Other antigens showed no significant changes.(ABSTRACT TRUNCATED AT 250 WORDS)

Original languageEnglish
Pages (from-to)737-743
Number of pages7
JournalNippon Naibunpi Gakkai zasshi
Volume61
Issue number7
DOIs
Publication statusPublished - Jan 1 1985
Externally publishedYes

Fingerprint

Subacute Thyroiditis
Histocompatibility Testing
Viral Antibodies
HLA-C Antigens
Paramyxoviridae Infections
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Virus Diseases
Human Influenza
Viruses
Antigens

Cite this

Kobayashi, N., Tamai, H., Nagai, K., Matsubayashi, S., Matsuzuka, F., Kuma, K., ... Nagataki, S. (1985). Studies on the pathogenesis of subacute thyroiditis. Nippon Naibunpi Gakkai zasshi, 61(7), 737-743. https://doi.org/10.1507/endocrine1927.61.7_737

Studies on the pathogenesis of subacute thyroiditis. / Kobayashi, N.; Tamai, H.; Nagai, K.; Matsubayashi, S.; Matsuzuka, F.; Kuma, K.; Goto, H.; Uno, H.; Sasazuki, Takehiko; Nagataki, S.

In: Nippon Naibunpi Gakkai zasshi, Vol. 61, No. 7, 01.01.1985, p. 737-743.

Research output: Contribution to journalArticle

Kobayashi, N, Tamai, H, Nagai, K, Matsubayashi, S, Matsuzuka, F, Kuma, K, Goto, H, Uno, H, Sasazuki, T & Nagataki, S 1985, 'Studies on the pathogenesis of subacute thyroiditis', Nippon Naibunpi Gakkai zasshi, vol. 61, no. 7, pp. 737-743. https://doi.org/10.1507/endocrine1927.61.7_737
Kobayashi N, Tamai H, Nagai K, Matsubayashi S, Matsuzuka F, Kuma K et al. Studies on the pathogenesis of subacute thyroiditis. Nippon Naibunpi Gakkai zasshi. 1985 Jan 1;61(7):737-743. https://doi.org/10.1507/endocrine1927.61.7_737
Kobayashi, N. ; Tamai, H. ; Nagai, K. ; Matsubayashi, S. ; Matsuzuka, F. ; Kuma, K. ; Goto, H. ; Uno, H. ; Sasazuki, Takehiko ; Nagataki, S. / Studies on the pathogenesis of subacute thyroiditis. In: Nippon Naibunpi Gakkai zasshi. 1985 ; Vol. 61, No. 7. pp. 737-743.
@article{6a164d4fcdce4fb1bf9f203ea44a7f9b,
title = "Studies on the pathogenesis of subacute thyroiditis",
abstract = "Despite the fact that subacute thyroiditis (SAT) is a common disease, its pathogenesis is still uncertain. At present, viral infection is simply thought to be a possible pathogenic factor. In Caucasians and Chinese, however, a strong association has recently been found between HLA-Bw35 and SAT. Therefore, genetic factors are also thought to participate in the onset of SAT. In this study we have further attempted to clarify the pathogenesis of this disease in this regard. Protocol: HLA typing for A, B and C loci (class I antigens) was performed on 89 patients with SAT (males: 7, females: 82) aged from 23 to 66 years, and DR and MT loci (class II antigens) were investigated in 55 patients. In 12 patients, viral antibody titers were measured as soon as possible after onset and two weeks later. The viral antibodies evaluated were those of Influenza A and B, Coxsackie A9, B1, B2, B3, B4, B5 and B6, Echo 3, 7, 11 and 12, Parainfluenza 1, 2, 3 and 4, and Adeno 8 virus. The following results were obtained: In class I HLA typing, the frequency of HLA-Bw35 in SAT was 67.4{\%}, which was significantly (p less than 0.0001) higher than that in the control (14.1{\%}). On the other hand, the frequency of Cw1 in SAT (14.6{\%}) was significantly (p less than 0.01) lower than that of the control (32.1{\%}), and that of Cw3 (65.2{\%}) was significantly (p less than 0.01) higher than that of the control (46.5{\%}). In class II HLA typing, the frequency of DRw8 in SAT was 38.2{\%}, which was significantly (p less than 0.05) higher than that of the control (21.9{\%}). Other antigens showed no significant changes.(ABSTRACT TRUNCATED AT 250 WORDS)",
author = "N. Kobayashi and H. Tamai and K. Nagai and S. Matsubayashi and F. Matsuzuka and K. Kuma and H. Goto and H. Uno and Takehiko Sasazuki and S. Nagataki",
year = "1985",
month = "1",
day = "1",
doi = "10.1507/endocrine1927.61.7_737",
language = "English",
volume = "61",
pages = "737--743",
journal = "Nippon Naibunpi Gakkai zasshi",
issn = "0029-0661",
number = "7",

}

TY - JOUR

T1 - Studies on the pathogenesis of subacute thyroiditis

AU - Kobayashi, N.

AU - Tamai, H.

AU - Nagai, K.

AU - Matsubayashi, S.

AU - Matsuzuka, F.

AU - Kuma, K.

AU - Goto, H.

AU - Uno, H.

AU - Sasazuki, Takehiko

AU - Nagataki, S.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - Despite the fact that subacute thyroiditis (SAT) is a common disease, its pathogenesis is still uncertain. At present, viral infection is simply thought to be a possible pathogenic factor. In Caucasians and Chinese, however, a strong association has recently been found between HLA-Bw35 and SAT. Therefore, genetic factors are also thought to participate in the onset of SAT. In this study we have further attempted to clarify the pathogenesis of this disease in this regard. Protocol: HLA typing for A, B and C loci (class I antigens) was performed on 89 patients with SAT (males: 7, females: 82) aged from 23 to 66 years, and DR and MT loci (class II antigens) were investigated in 55 patients. In 12 patients, viral antibody titers were measured as soon as possible after onset and two weeks later. The viral antibodies evaluated were those of Influenza A and B, Coxsackie A9, B1, B2, B3, B4, B5 and B6, Echo 3, 7, 11 and 12, Parainfluenza 1, 2, 3 and 4, and Adeno 8 virus. The following results were obtained: In class I HLA typing, the frequency of HLA-Bw35 in SAT was 67.4%, which was significantly (p less than 0.0001) higher than that in the control (14.1%). On the other hand, the frequency of Cw1 in SAT (14.6%) was significantly (p less than 0.01) lower than that of the control (32.1%), and that of Cw3 (65.2%) was significantly (p less than 0.01) higher than that of the control (46.5%). In class II HLA typing, the frequency of DRw8 in SAT was 38.2%, which was significantly (p less than 0.05) higher than that of the control (21.9%). Other antigens showed no significant changes.(ABSTRACT TRUNCATED AT 250 WORDS)

AB - Despite the fact that subacute thyroiditis (SAT) is a common disease, its pathogenesis is still uncertain. At present, viral infection is simply thought to be a possible pathogenic factor. In Caucasians and Chinese, however, a strong association has recently been found between HLA-Bw35 and SAT. Therefore, genetic factors are also thought to participate in the onset of SAT. In this study we have further attempted to clarify the pathogenesis of this disease in this regard. Protocol: HLA typing for A, B and C loci (class I antigens) was performed on 89 patients with SAT (males: 7, females: 82) aged from 23 to 66 years, and DR and MT loci (class II antigens) were investigated in 55 patients. In 12 patients, viral antibody titers were measured as soon as possible after onset and two weeks later. The viral antibodies evaluated were those of Influenza A and B, Coxsackie A9, B1, B2, B3, B4, B5 and B6, Echo 3, 7, 11 and 12, Parainfluenza 1, 2, 3 and 4, and Adeno 8 virus. The following results were obtained: In class I HLA typing, the frequency of HLA-Bw35 in SAT was 67.4%, which was significantly (p less than 0.0001) higher than that in the control (14.1%). On the other hand, the frequency of Cw1 in SAT (14.6%) was significantly (p less than 0.01) lower than that of the control (32.1%), and that of Cw3 (65.2%) was significantly (p less than 0.01) higher than that of the control (46.5%). In class II HLA typing, the frequency of DRw8 in SAT was 38.2%, which was significantly (p less than 0.05) higher than that of the control (21.9%). Other antigens showed no significant changes.(ABSTRACT TRUNCATED AT 250 WORDS)

UR - http://www.scopus.com/inward/record.url?scp=0022429504&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022429504&partnerID=8YFLogxK

U2 - 10.1507/endocrine1927.61.7_737

DO - 10.1507/endocrine1927.61.7_737

M3 - Article

VL - 61

SP - 737

EP - 743

JO - Nippon Naibunpi Gakkai zasshi

JF - Nippon Naibunpi Gakkai zasshi

SN - 0029-0661

IS - 7

ER -