Study of the EDA(+) fibronectin recognition structure on heparin

K. Miyamoto, T. Ito, R. Maeda, Masayuki Tokita, T. Komai, K. Miyashita, E. Sakashita

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Abstract

We carried out research into an absorber to remove EDA (+) fibronectin (EDA(+)FN) from the blood by using heparin. The elucidation of the EDA(+)FN recognition structure of the heparin is necessary for the development of the effective material. In this study, the examination of recognition structure for EDA (+)FN was carried out by using desulfate heparin and the heparin oligomer. The association constant (KA) of EDA(+)FN and the heparin decreased gradually (1.0E + 8 ← 1.0 E+7 M-1) with desulfate treatment. There was hardly the change in KA with the decline of the molecular weight. As for the EDA (+) FN recognition structure of the heparin, our results showed that it was a low molecular weight level (less than MW= 1.0 E + 3). We also found that the peculiar arrangement structure was not necessary.

Original languageEnglish
Pages (from-to)191-195
Number of pages5
JournalJapanese Journal of Artificial Organs
Volume28
Issue number1
Publication statusPublished - Jan 1 1999

All Science Journal Classification (ASJC) codes

  • Biophysics

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    Miyamoto, K., Ito, T., Maeda, R., Tokita, M., Komai, T., Miyashita, K., & Sakashita, E. (1999). Study of the EDA(+) fibronectin recognition structure on heparin. Japanese Journal of Artificial Organs, 28(1), 191-195.