Fleroxacin (FLRX) was given orally at 200mg once daily for 7 days to 218 patients with non-catheterized complicated urinary tract infections. The overall clinical efficacy rate according to the criteria proposed by the Japanese UTI Committee, was 75.4% (129/171). 129 patients who had been evaluated as excellent or moderate following initial treatment with FLRX, were assigned randomly to 3 groups. Group A was not treated. Group B was treated with 100mg of FLRX once daily for 28 days, and Group C was treated with 100mg of FLRX and clarithromycin (CAM) once daily for 28 days. With the occurrence of pyuria and bacteriuria as markers, the recurrence rates were 56.9%, 29.3% and 47.5% in Groups A, B, and C at 12 weeks, respectively, with no statistically significant difference. According to a breakdown of cases with bacteriuria only, the recurrence rates were 71.7%, 52.3% and 74.5% in Groups A, B and C respectively, with no statistically significant difference.
|Number of pages||10|
|Journal||Nishinihon Journal of Urology|
|Publication status||Published - Jan 1 1998|
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