Study on clinical effects and recurrence of fleroxacin for the treatment of complicated urinary tract infections

T. Matsumoto, J. Kumazawa, K. Takahashi, T. Takesue, A. Yamaguchi, K. Tatsugami, H. Kawano, Y. Sakamoto, H. Kuramoto, K. Takayama, Y. Mihara, M. Kano, S. Andoh, K. Itoh, T. Matsui, S. Kamidono, S. Ka, M. Kominami, M. Hazama, Y. HasunumaH. Ohoka, A. Hayashi, A. Takenaka, N. Kataoka, M. Sugimoto, H. Miyazaki, I. Nakamura, H. Tanaka, K. Minayoshi, K. Tanaka, K. Umezu, M. Shinozaki, I. Tsuzi, N. Ito, Y. Nakano, H. Chokyu, M. Harada, Y. Nakagawa, K. Kikuchi, H. Akaza, K. Koiso, M. Ohtani, F. Manabe, S. Saito, F. Kondo, M. Tomobe, R. Noguchi, S. Yoshii, A. Tsuruta, S. Ishikawa, M. Tsutsumi, Y. Sawae

Research output: Contribution to journalArticle

Abstract

Fleroxacin (FLRX) was given orally at 200mg once daily for 7 days to 218 patients with non-catheterized complicated urinary tract infections. The overall clinical efficacy rate according to the criteria proposed by the Japanese UTI Committee, was 75.4% (129/171). 129 patients who had been evaluated as excellent or moderate following initial treatment with FLRX, were assigned randomly to 3 groups. Group A was not treated. Group B was treated with 100mg of FLRX once daily for 28 days, and Group C was treated with 100mg of FLRX and clarithromycin (CAM) once daily for 28 days. With the occurrence of pyuria and bacteriuria as markers, the recurrence rates were 56.9%, 29.3% and 47.5% in Groups A, B, and C at 12 weeks, respectively, with no statistically significant difference. According to a breakdown of cases with bacteriuria only, the recurrence rates were 71.7%, 52.3% and 74.5% in Groups A, B and C respectively, with no statistically significant difference.

Original languageEnglish
Pages (from-to)567-576
Number of pages10
JournalNishinihon Journal of Urology
Volume60
Issue number7
Publication statusPublished - Jan 1 1998

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All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Matsumoto, T., Kumazawa, J., Takahashi, K., Takesue, T., Yamaguchi, A., Tatsugami, K., ... Sawae, Y. (1998). Study on clinical effects and recurrence of fleroxacin for the treatment of complicated urinary tract infections. Nishinihon Journal of Urology, 60(7), 567-576.