Abstract
Recent years, much attention has been paid to tissue engineering for bone regeneration. In current orthopedic titatments, artificial bone substitutes composed of bioactive ceramics are sometimes used instead of autograft and allograft to obtain bone tissue ingrowth in damaged regions. In this study, nonabsothable porous bioceramics was implanted into femur of rabbits to perform in vivo study of bone regeneration. Compression mechanical properties were then evaluated afier implantation for fixed periods up to 48weeks. 3D finite element models were also constructed using the ji-CT images taken afier implantation. Computational analysis was conducted under a compressive loading condition and the effects of bone tissue ingrowth on the mechanical properties of the bioceramics specimen at each stage. Both experimental and computational results clearly showed that compitssive modulus increased from 1 to 24weeks and then decreased up to 48 weeks. It is presumed that bone tissue was regenerated excessively for 12 weeks and then, bone tissue tried to keep a steady state condition by remodeling.
| Original language | English |
|---|---|
| Pages (from-to) | 784-788 |
| Number of pages | 5 |
| Journal | Nihon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A |
| Volume | 77 |
| Issue number | 777 |
| Publication status | Published - 2011 |
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All Science Journal Classification (ASJC) codes
- Mechanical Engineering
- Mechanics of Materials
- Materials Science(all)
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Study on the mechanical properties of porous bioceramics varied by bone tissue formation. / Arahira, Takaaki; Todo, Mitsugu; Myoui, Akira.
In: Nihon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A, Vol. 77, No. 777, 2011, p. 784-788.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Study on the mechanical properties of porous bioceramics varied by bone tissue formation
AU - Arahira, Takaaki
AU - Todo, Mitsugu
AU - Myoui, Akira
PY - 2011
Y1 - 2011
N2 - Recent years, much attention has been paid to tissue engineering for bone regeneration. In current orthopedic titatments, artificial bone substitutes composed of bioactive ceramics are sometimes used instead of autograft and allograft to obtain bone tissue ingrowth in damaged regions. In this study, nonabsothable porous bioceramics was implanted into femur of rabbits to perform in vivo study of bone regeneration. Compression mechanical properties were then evaluated afier implantation for fixed periods up to 48weeks. 3D finite element models were also constructed using the ji-CT images taken afier implantation. Computational analysis was conducted under a compressive loading condition and the effects of bone tissue ingrowth on the mechanical properties of the bioceramics specimen at each stage. Both experimental and computational results clearly showed that compitssive modulus increased from 1 to 24weeks and then decreased up to 48 weeks. It is presumed that bone tissue was regenerated excessively for 12 weeks and then, bone tissue tried to keep a steady state condition by remodeling.
AB - Recent years, much attention has been paid to tissue engineering for bone regeneration. In current orthopedic titatments, artificial bone substitutes composed of bioactive ceramics are sometimes used instead of autograft and allograft to obtain bone tissue ingrowth in damaged regions. In this study, nonabsothable porous bioceramics was implanted into femur of rabbits to perform in vivo study of bone regeneration. Compression mechanical properties were then evaluated afier implantation for fixed periods up to 48weeks. 3D finite element models were also constructed using the ji-CT images taken afier implantation. Computational analysis was conducted under a compressive loading condition and the effects of bone tissue ingrowth on the mechanical properties of the bioceramics specimen at each stage. Both experimental and computational results clearly showed that compitssive modulus increased from 1 to 24weeks and then decreased up to 48 weeks. It is presumed that bone tissue was regenerated excessively for 12 weeks and then, bone tissue tried to keep a steady state condition by remodeling.
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M3 - Article
AN - SCOPUS:84856447192
VL - 77
SP - 784
EP - 788
JO - Nihon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A
JF - Nihon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A
SN - 0387-5008
IS - 777
ER -