Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice

Tomoharu Yasuda, Tristan Wirtz, Baochun Zhang, Thomas Wunderlich, Marc Schmidt-Supprian, Thomas Sommermann, Klaus Rajewsky

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV) is a γ herpes virus endemic in humans and transforming human B lymphocytes. It causes a variety of human pathologies ranging from infectious mononucleosis upon acute infection to EBV-driven B-cell lymphomas. In humans, EBV-infected cells are under powerful immune surveillance by T and NK cells. If this immune surveillance is compromised as in immunosuppressed (AIDS- or posttransplantation) patients, the virus can spread from rare, EBV-containing cells and cause life-threatening pathologies.We have found that EBV immune surveillance and lymphomagenesis can be modeled in mice by targeted expression of key EBV proteins in the B-cell lineage. As EBV does not infect mouse B cells and mice have thus not coevolved with the virus, EBV exploits basic modes of the host immune response to optimize its coexistence with the host.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalCold Spring Harbor Symposia on Quantitative Biology
Volume78
Issue number1
DOIs
Publication statusPublished - Jan 1 2013
Externally publishedYes

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Epstein-Barr Virus Infections
Pathology
Human Herpesvirus 4
Viruses
B-Lymphocytes
Cells
Infectious Mononucleosis
B-Cell Lymphoma
Cell Lineage
Natural Killer Cells
Acquired Immunodeficiency Syndrome
Lymphocytes
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice. / Yasuda, Tomoharu; Wirtz, Tristan; Zhang, Baochun; Wunderlich, Thomas; Schmidt-Supprian, Marc; Sommermann, Thomas; Rajewsky, Klaus.

In: Cold Spring Harbor Symposia on Quantitative Biology, Vol. 78, No. 1, 01.01.2013, p. 259-263.

Research output: Contribution to journalArticle

Yasuda, Tomoharu ; Wirtz, Tristan ; Zhang, Baochun ; Wunderlich, Thomas ; Schmidt-Supprian, Marc ; Sommermann, Thomas ; Rajewsky, Klaus. / Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice. In: Cold Spring Harbor Symposia on Quantitative Biology. 2013 ; Vol. 78, No. 1. pp. 259-263.
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