Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice

Tomoharu Yasuda, Tristan Wirtz, Baochun Zhang, Thomas Wunderlich, Marc Schmidt-Supprian, Thomas Sommermann, Klaus Rajewsky

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Abstract

Epstein-Barr virus (EBV) is a γ herpes virus endemic in humans and transforming human B lymphocytes. It causes a variety of human pathologies ranging from infectious mononucleosis upon acute infection to EBV-driven B-cell lymphomas. In humans, EBV-infected cells are under powerful immune surveillance by T and NK cells. If this immune surveillance is compromised as in immunosuppressed (AIDS- or posttransplantation) patients, the virus can spread from rare, EBV-containing cells and cause life-threatening pathologies.We have found that EBV immune surveillance and lymphomagenesis can be modeled in mice by targeted expression of key EBV proteins in the B-cell lineage. As EBV does not infect mouse B cells and mice have thus not coevolved with the virus, EBV exploits basic modes of the host immune response to optimize its coexistence with the host.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalCold Spring Harbor Symposia on Quantitative Biology
Volume78
Issue number1
DOIs
Publication statusPublished - 2013

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Yasuda, T., Wirtz, T., Zhang, B., Wunderlich, T., Schmidt-Supprian, M., Sommermann, T., & Rajewsky, K. (2013). Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice. Cold Spring Harbor Symposia on Quantitative Biology, 78(1), 259-263. https://doi.org/10.1101/sqb.2013.78.020222