TY - JOUR
T1 - Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice
AU - Yasuda, Tomoharu
AU - Wirtz, Tristan
AU - Zhang, Baochun
AU - Wunderlich, Thomas
AU - Schmidt-Supprian, Marc
AU - Sommermann, Thomas
AU - Rajewsky, Klaus
PY - 2013
Y1 - 2013
N2 - Epstein-Barr virus (EBV) is a γ herpes virus endemic in humans and transforming human B lymphocytes. It causes a variety of human pathologies ranging from infectious mononucleosis upon acute infection to EBV-driven B-cell lymphomas. In humans, EBV-infected cells are under powerful immune surveillance by T and NK cells. If this immune surveillance is compromised as in immunosuppressed (AIDS- or posttransplantation) patients, the virus can spread from rare, EBV-containing cells and cause life-threatening pathologies.We have found that EBV immune surveillance and lymphomagenesis can be modeled in mice by targeted expression of key EBV proteins in the B-cell lineage. As EBV does not infect mouse B cells and mice have thus not coevolved with the virus, EBV exploits basic modes of the host immune response to optimize its coexistence with the host.
AB - Epstein-Barr virus (EBV) is a γ herpes virus endemic in humans and transforming human B lymphocytes. It causes a variety of human pathologies ranging from infectious mononucleosis upon acute infection to EBV-driven B-cell lymphomas. In humans, EBV-infected cells are under powerful immune surveillance by T and NK cells. If this immune surveillance is compromised as in immunosuppressed (AIDS- or posttransplantation) patients, the virus can spread from rare, EBV-containing cells and cause life-threatening pathologies.We have found that EBV immune surveillance and lymphomagenesis can be modeled in mice by targeted expression of key EBV proteins in the B-cell lineage. As EBV does not infect mouse B cells and mice have thus not coevolved with the virus, EBV exploits basic modes of the host immune response to optimize its coexistence with the host.
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U2 - 10.1101/sqb.2013.78.020222
DO - 10.1101/sqb.2013.78.020222
M3 - Article
C2 - 24241423
AN - SCOPUS:84904875828
SN - 0091-7451
VL - 78
SP - 259
EP - 263
JO - Cold Spring Harbor Symposia on Quantitative Biology
JF - Cold Spring Harbor Symposia on Quantitative Biology
IS - 1
ER -
