Subclinical carotid atherosclerosis and hyperuricemia in relation to renal impairment in a rural Japanese population

The Nagasaki Islands study

Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mami Tamai, Koichiro Kadota, Kazuhiko Arima, Hironori Yamasaki, Noboru Takamura, Kiyoshi Aoyagi, Takahiro Maeda

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: The influence of hyperuricemia on atherosclerosis is controversial. Subclinical carotid atherosclerosis can be defined in two ways in terms of mean and maximum carotid intima-media thickness (CIMT): one with mean CIMT≥1.1mm and the other with maximum CIMT≥1.1mm. However, no studies have been reported of the association between hyperuricemia and subclinical carotid atherosclerosis while taking the two different ways of classification into account. Methods: We conducted a cross-sectional study of 4133 subjects (1492 men and 2641 women) aged 30-89 years undergoing general health check-ups. For analysis of various associations, we calculated the multivariable odds ratios (ORs) for the two ways classifications of subclinical carotid atherosclerosis in relation to hyperuricemia. Results: Hyperuricemia-related renal impairment constitutes a significant marker for subclinical carotid atherosclerosis with mean CIMT≥1.1mm for both men and women, while hyperuricemia per se was found to be beneficially associated with risk of subclinical carotid atherosclerosis with maximum CIMT≥1.1mm for men. The classical cardiovascular risk factors without adjustment for glomerular filtration rate (GFR) of ORs for subclinical carotid atherosclerosis (mean CIMT≥1.1mm) and subclinical carotid atherosclerosis (maximum CIMT≥1.1mm) were 2.20(1.10-4.22) and 0.84(0.63-1.13) for men and 2.12(1.02-4.38) and 0.92(0.66-1.27) for women. After further adjustment for GFR, the corresponding values were 1.54(0.74-3.20) and 0.67(0.49-0.92) for men and 1.32(0.61-2.88) and 0.80(0.57-1.12) for women. Conclusion: Hyperuricemia-related renal impairment is a significant marker for subclinical carotid atherosclerosis for both men and women, while hyperuricemia per se may be inversely associated with subclinical carotid atherosclerosis for men as seen in a rural community-dwelling Japanese population.

Original languageEnglish
Pages (from-to)525-529
Number of pages5
JournalAtherosclerosis
Volume233
Issue number2
DOIs
Publication statusPublished - Jan 1 2014

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Hyperuricemia
Carotid Artery Diseases
Rural Population
Islands
Kidney
Glomerular Filtration Rate
Odds Ratio
Independent Living
Carotid Intima-Media Thickness
Atherosclerosis
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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Subclinical carotid atherosclerosis and hyperuricemia in relation to renal impairment in a rural Japanese population : The Nagasaki Islands study. / Shimizu, Yuji; Sato, Shimpei; Koyamatsu, Jun; Yamanashi, Hirotomo; Tamai, Mami; Kadota, Koichiro; Arima, Kazuhiko; Yamasaki, Hironori; Takamura, Noboru; Aoyagi, Kiyoshi; Maeda, Takahiro.

In: Atherosclerosis, Vol. 233, No. 2, 01.01.2014, p. 525-529.

Research output: Contribution to journalArticle

Shimizu, Y, Sato, S, Koyamatsu, J, Yamanashi, H, Tamai, M, Kadota, K, Arima, K, Yamasaki, H, Takamura, N, Aoyagi, K & Maeda, T 2014, 'Subclinical carotid atherosclerosis and hyperuricemia in relation to renal impairment in a rural Japanese population: The Nagasaki Islands study', Atherosclerosis, vol. 233, no. 2, pp. 525-529. https://doi.org/10.1016/j.atherosclerosis.2014.01.033
Shimizu, Yuji ; Sato, Shimpei ; Koyamatsu, Jun ; Yamanashi, Hirotomo ; Tamai, Mami ; Kadota, Koichiro ; Arima, Kazuhiko ; Yamasaki, Hironori ; Takamura, Noboru ; Aoyagi, Kiyoshi ; Maeda, Takahiro. / Subclinical carotid atherosclerosis and hyperuricemia in relation to renal impairment in a rural Japanese population : The Nagasaki Islands study. In: Atherosclerosis. 2014 ; Vol. 233, No. 2. pp. 525-529.
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abstract = "Objective: The influence of hyperuricemia on atherosclerosis is controversial. Subclinical carotid atherosclerosis can be defined in two ways in terms of mean and maximum carotid intima-media thickness (CIMT): one with mean CIMT≥1.1mm and the other with maximum CIMT≥1.1mm. However, no studies have been reported of the association between hyperuricemia and subclinical carotid atherosclerosis while taking the two different ways of classification into account. Methods: We conducted a cross-sectional study of 4133 subjects (1492 men and 2641 women) aged 30-89 years undergoing general health check-ups. For analysis of various associations, we calculated the multivariable odds ratios (ORs) for the two ways classifications of subclinical carotid atherosclerosis in relation to hyperuricemia. Results: Hyperuricemia-related renal impairment constitutes a significant marker for subclinical carotid atherosclerosis with mean CIMT≥1.1mm for both men and women, while hyperuricemia per se was found to be beneficially associated with risk of subclinical carotid atherosclerosis with maximum CIMT≥1.1mm for men. The classical cardiovascular risk factors without adjustment for glomerular filtration rate (GFR) of ORs for subclinical carotid atherosclerosis (mean CIMT≥1.1mm) and subclinical carotid atherosclerosis (maximum CIMT≥1.1mm) were 2.20(1.10-4.22) and 0.84(0.63-1.13) for men and 2.12(1.02-4.38) and 0.92(0.66-1.27) for women. After further adjustment for GFR, the corresponding values were 1.54(0.74-3.20) and 0.67(0.49-0.92) for men and 1.32(0.61-2.88) and 0.80(0.57-1.12) for women. Conclusion: Hyperuricemia-related renal impairment is a significant marker for subclinical carotid atherosclerosis for both men and women, while hyperuricemia per se may be inversely associated with subclinical carotid atherosclerosis for men as seen in a rural community-dwelling Japanese population.",
author = "Yuji Shimizu and Shimpei Sato and Jun Koyamatsu and Hirotomo Yamanashi and Mami Tamai and Koichiro Kadota and Kazuhiko Arima and Hironori Yamasaki and Noboru Takamura and Kiyoshi Aoyagi and Takahiro Maeda",
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T1 - Subclinical carotid atherosclerosis and hyperuricemia in relation to renal impairment in a rural Japanese population

T2 - The Nagasaki Islands study

AU - Shimizu, Yuji

AU - Sato, Shimpei

AU - Koyamatsu, Jun

AU - Yamanashi, Hirotomo

AU - Tamai, Mami

AU - Kadota, Koichiro

AU - Arima, Kazuhiko

AU - Yamasaki, Hironori

AU - Takamura, Noboru

AU - Aoyagi, Kiyoshi

AU - Maeda, Takahiro

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective: The influence of hyperuricemia on atherosclerosis is controversial. Subclinical carotid atherosclerosis can be defined in two ways in terms of mean and maximum carotid intima-media thickness (CIMT): one with mean CIMT≥1.1mm and the other with maximum CIMT≥1.1mm. However, no studies have been reported of the association between hyperuricemia and subclinical carotid atherosclerosis while taking the two different ways of classification into account. Methods: We conducted a cross-sectional study of 4133 subjects (1492 men and 2641 women) aged 30-89 years undergoing general health check-ups. For analysis of various associations, we calculated the multivariable odds ratios (ORs) for the two ways classifications of subclinical carotid atherosclerosis in relation to hyperuricemia. Results: Hyperuricemia-related renal impairment constitutes a significant marker for subclinical carotid atherosclerosis with mean CIMT≥1.1mm for both men and women, while hyperuricemia per se was found to be beneficially associated with risk of subclinical carotid atherosclerosis with maximum CIMT≥1.1mm for men. The classical cardiovascular risk factors without adjustment for glomerular filtration rate (GFR) of ORs for subclinical carotid atherosclerosis (mean CIMT≥1.1mm) and subclinical carotid atherosclerosis (maximum CIMT≥1.1mm) were 2.20(1.10-4.22) and 0.84(0.63-1.13) for men and 2.12(1.02-4.38) and 0.92(0.66-1.27) for women. After further adjustment for GFR, the corresponding values were 1.54(0.74-3.20) and 0.67(0.49-0.92) for men and 1.32(0.61-2.88) and 0.80(0.57-1.12) for women. Conclusion: Hyperuricemia-related renal impairment is a significant marker for subclinical carotid atherosclerosis for both men and women, while hyperuricemia per se may be inversely associated with subclinical carotid atherosclerosis for men as seen in a rural community-dwelling Japanese population.

AB - Objective: The influence of hyperuricemia on atherosclerosis is controversial. Subclinical carotid atherosclerosis can be defined in two ways in terms of mean and maximum carotid intima-media thickness (CIMT): one with mean CIMT≥1.1mm and the other with maximum CIMT≥1.1mm. However, no studies have been reported of the association between hyperuricemia and subclinical carotid atherosclerosis while taking the two different ways of classification into account. Methods: We conducted a cross-sectional study of 4133 subjects (1492 men and 2641 women) aged 30-89 years undergoing general health check-ups. For analysis of various associations, we calculated the multivariable odds ratios (ORs) for the two ways classifications of subclinical carotid atherosclerosis in relation to hyperuricemia. Results: Hyperuricemia-related renal impairment constitutes a significant marker for subclinical carotid atherosclerosis with mean CIMT≥1.1mm for both men and women, while hyperuricemia per se was found to be beneficially associated with risk of subclinical carotid atherosclerosis with maximum CIMT≥1.1mm for men. The classical cardiovascular risk factors without adjustment for glomerular filtration rate (GFR) of ORs for subclinical carotid atherosclerosis (mean CIMT≥1.1mm) and subclinical carotid atherosclerosis (maximum CIMT≥1.1mm) were 2.20(1.10-4.22) and 0.84(0.63-1.13) for men and 2.12(1.02-4.38) and 0.92(0.66-1.27) for women. After further adjustment for GFR, the corresponding values were 1.54(0.74-3.20) and 0.67(0.49-0.92) for men and 1.32(0.61-2.88) and 0.80(0.57-1.12) for women. Conclusion: Hyperuricemia-related renal impairment is a significant marker for subclinical carotid atherosclerosis for both men and women, while hyperuricemia per se may be inversely associated with subclinical carotid atherosclerosis for men as seen in a rural community-dwelling Japanese population.

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