Subclinical carotid atherosclerosis and hyperuricemia in relation to renal impairment in a rural Japanese population: The Nagasaki Islands study

Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mami Tamai, Koichiro Kadota, Kazuhiko Arima, Hironori Yamasaki, Noboru Takamura, Kiyoshi Aoyagi, Takahiro Maeda

Research output: Contribution to journalArticle

6 Citations (Scopus)


Objective: The influence of hyperuricemia on atherosclerosis is controversial. Subclinical carotid atherosclerosis can be defined in two ways in terms of mean and maximum carotid intima-media thickness (CIMT): one with mean CIMT≥1.1mm and the other with maximum CIMT≥1.1mm. However, no studies have been reported of the association between hyperuricemia and subclinical carotid atherosclerosis while taking the two different ways of classification into account. Methods: We conducted a cross-sectional study of 4133 subjects (1492 men and 2641 women) aged 30-89 years undergoing general health check-ups. For analysis of various associations, we calculated the multivariable odds ratios (ORs) for the two ways classifications of subclinical carotid atherosclerosis in relation to hyperuricemia. Results: Hyperuricemia-related renal impairment constitutes a significant marker for subclinical carotid atherosclerosis with mean CIMT≥1.1mm for both men and women, while hyperuricemia per se was found to be beneficially associated with risk of subclinical carotid atherosclerosis with maximum CIMT≥1.1mm for men. The classical cardiovascular risk factors without adjustment for glomerular filtration rate (GFR) of ORs for subclinical carotid atherosclerosis (mean CIMT≥1.1mm) and subclinical carotid atherosclerosis (maximum CIMT≥1.1mm) were 2.20(1.10-4.22) and 0.84(0.63-1.13) for men and 2.12(1.02-4.38) and 0.92(0.66-1.27) for women. After further adjustment for GFR, the corresponding values were 1.54(0.74-3.20) and 0.67(0.49-0.92) for men and 1.32(0.61-2.88) and 0.80(0.57-1.12) for women. Conclusion: Hyperuricemia-related renal impairment is a significant marker for subclinical carotid atherosclerosis for both men and women, while hyperuricemia per se may be inversely associated with subclinical carotid atherosclerosis for men as seen in a rural community-dwelling Japanese population.

Original languageEnglish
Pages (from-to)525-529
Number of pages5
Issue number2
Publication statusPublished - Apr 2014


All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this