TY - JOUR
T1 - Subcortical axonal loss with glial reactions following partial status epilepticus with neuroradiological findings of reduced subcortical diffusion
AU - Lee, Sooyoung
AU - Morioka, Takato
AU - Chong, Pin Fee
AU - Suzuki, Satoshi O.
AU - Imagi, Toru
AU - Murakami, Nobuya
AU - Baba, Hiroshi
AU - Kira, Ryutaro
N1 - Funding Information:
Funding information This research was supported in part by Fukuoka Children’s Hospital Research Fund.
Publisher Copyright:
© 2018, Springer-Verlag Italia S.r.l., part of Springer Nature.
PY - 2019/4/3
Y1 - 2019/4/3
N2 - Hyperintensity in the subcortical white matter on the diffusion-weighted magnetic resonance image has been described recently, in association with partial status epilepticus. Although this reduced subcortical diffusion is typically seen in patients with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD), the exact pathophysiological mechanism is unclear. We report the case of a 3-month-old boy who underwent surgery for intractable epilepsy associated with cortical dysplasia in the left peri-Rolandic area, coincident with the appearance of reduced subcortical diffusion. Neurohistological findings revealed that the most prominent finding was axonal loss with marked astroglial and microglial reactions in the white matter. Neither degenerated neurons nor neurophagocytic microglial accumulation was evident in the cortex. These findings confirm that white matter can be secondarily damaged in patients with partial status epilepticus, and possible pathomechanism of reduced subcortical diffusion is discussed.
AB - Hyperintensity in the subcortical white matter on the diffusion-weighted magnetic resonance image has been described recently, in association with partial status epilepticus. Although this reduced subcortical diffusion is typically seen in patients with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD), the exact pathophysiological mechanism is unclear. We report the case of a 3-month-old boy who underwent surgery for intractable epilepsy associated with cortical dysplasia in the left peri-Rolandic area, coincident with the appearance of reduced subcortical diffusion. Neurohistological findings revealed that the most prominent finding was axonal loss with marked astroglial and microglial reactions in the white matter. Neither degenerated neurons nor neurophagocytic microglial accumulation was evident in the cortex. These findings confirm that white matter can be secondarily damaged in patients with partial status epilepticus, and possible pathomechanism of reduced subcortical diffusion is discussed.
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U2 - 10.1007/s10072-018-3635-4
DO - 10.1007/s10072-018-3635-4
M3 - Article
C2 - 30443827
AN - SCOPUS:85056697198
VL - 40
SP - 851
EP - 855
JO - Italian Journal of Neurological Sciences
JF - Italian Journal of Neurological Sciences
SN - 1590-1874
IS - 4
ER -