TY - JOUR
T1 - Subcutaneous panniculitis by Epstein-Barr virus-infected natural killer (NK) cell proliferation in aggressive subcutaneous NK cell lymphoma
AU - Abe, Yasunobu
AU - Muta, Koichiro
AU - Ohshima, Koichi
AU - Yasumoto, Shinichiro
AU - Shiratsuchi, Motoaki
AU - Saito, Ryoko
AU - Tsujita, Jun
AU - Shibata, Tomoko
AU - Furue, Masutaka
AU - Kikuchi, Masahiro
AU - Nishimura, Junji
AU - Nawata, Hajime
PY - 2000
Y1 - 2000
N2 - We describe here a case involving a patient presenting initially with subcutaneous panniculitis, which developed after 12 years into aggressive subcutaneous natural killer (NK) cell lymphoma with peripheral blood involvement and hemophagocytosis. The surface marker of lymphoid cells in peripheral blood was CD2+3-7+8-16+56+. Skin biopsies were taken in May 1986 and June 1998. The initial biopsy revealed a diffuse proliferation of atypical lymphoid cells in the subcutaneous tissue with panniculitis, while the second biopsy revealed the presence of large lymphoid cells in the subcutaneous tissue with necrotic changes, consistent with a diagnosis of malignant lymphoma (diffuse pleomorphic type). The lymphoid cells from these two specimens were positive for CD56 and such cytotoxic molecules as T-cell intracellular antigen-1 (TIA-1), granzyme B, and, interestingly, also positive for Epstein-Barr (EB) virus by in situ hybridization. This suggests that chronic EB virus infections play an important role in the early stages of tumorigenesis and in the progression of NK cell lymphoproliferative disorders. (C) 2000 Wiley-Liss, Inc.
AB - We describe here a case involving a patient presenting initially with subcutaneous panniculitis, which developed after 12 years into aggressive subcutaneous natural killer (NK) cell lymphoma with peripheral blood involvement and hemophagocytosis. The surface marker of lymphoid cells in peripheral blood was CD2+3-7+8-16+56+. Skin biopsies were taken in May 1986 and June 1998. The initial biopsy revealed a diffuse proliferation of atypical lymphoid cells in the subcutaneous tissue with panniculitis, while the second biopsy revealed the presence of large lymphoid cells in the subcutaneous tissue with necrotic changes, consistent with a diagnosis of malignant lymphoma (diffuse pleomorphic type). The lymphoid cells from these two specimens were positive for CD56 and such cytotoxic molecules as T-cell intracellular antigen-1 (TIA-1), granzyme B, and, interestingly, also positive for Epstein-Barr (EB) virus by in situ hybridization. This suggests that chronic EB virus infections play an important role in the early stages of tumorigenesis and in the progression of NK cell lymphoproliferative disorders. (C) 2000 Wiley-Liss, Inc.
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U2 - 10.1002/1096-8652(200007)64:3<221::AID-AJH16>3.0.CO;2-N
DO - 10.1002/1096-8652(200007)64:3<221::AID-AJH16>3.0.CO;2-N
M3 - Article
C2 - 10861822
AN - SCOPUS:0034044321
VL - 64
SP - 221
EP - 225
JO - American Journal of Hematology
JF - American Journal of Hematology
SN - 0361-8609
IS - 3
ER -