D -Serine reflects kidney function and diseases

Atsushi Hesaka, Shinsuke Sakai, Kenji Hamase, Tatsuhiko Ikeda, Rakan Matsui, Masashi Mita, Masaru Horio, Yoshitaka Isaka, Tomonori Kimura

Research output: Contribution to journalArticle

Abstract

D -Amino acids, long-term undetected enantiomers of L -amino acids, are now emerging as potential biomarkers, especially for kidney diseases. Management of chronic kidney disease (CKD), a global problem with its high prevalence and poor prognosis, is currently unsatisfactory due to the difficulty in estimating kidney function and in early detection of diseases. We now show that intra-body dynamics of D -serine reflect kidney function and diseases. The blood level of D -serine correlated well with the actual glomerular filtration ratio, a key kidney function. This correlation was compatible with those of conventional kidney markers, and blood level of D -serine was relatively unaffected by such clinical factors as body size. The balance between excretion and reabsorption of amino acids by the kidney was controlled with chiral selectivity, and the reabsorption of D -serine was sensitive to the presence of CKD. The combination of blood level and urinary dynamics of D -serine effectively distinguished CKD from non-CKD. These lines of evidence provide new insights into the enantioselective amino acid dynamics in the human body that reflect disease pathophysiology. D -Serine may serve as a vital biomarker that suppress CKD onset through the precise assessment of kidney function and the diagnosis of CKD.

Original languageEnglish
Article number5104
JournalScientific reports
Volume9
Issue number1
DOIs
Publication statusPublished - Dec 1 2019

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Kidney Diseases
Serine
Chronic Renal Insufficiency
Kidney
Amino Acids
Biomarkers
Body Size
Human Body
Early Diagnosis

All Science Journal Classification (ASJC) codes

  • General

Cite this

Hesaka, A., Sakai, S., Hamase, K., Ikeda, T., Matsui, R., Mita, M., ... Kimura, T. (2019). D -Serine reflects kidney function and diseases Scientific reports, 9(1), [5104]. https://doi.org/10.1038/s41598-019-41608-0

D -Serine reflects kidney function and diseases . / Hesaka, Atsushi; Sakai, Shinsuke; Hamase, Kenji; Ikeda, Tatsuhiko; Matsui, Rakan; Mita, Masashi; Horio, Masaru; Isaka, Yoshitaka; Kimura, Tomonori.

In: Scientific reports, Vol. 9, No. 1, 5104, 01.12.2019.

Research output: Contribution to journalArticle

Hesaka, A, Sakai, S, Hamase, K, Ikeda, T, Matsui, R, Mita, M, Horio, M, Isaka, Y & Kimura, T 2019, 'D -Serine reflects kidney function and diseases ' Scientific reports, vol. 9, no. 1, 5104. https://doi.org/10.1038/s41598-019-41608-0
Hesaka, Atsushi ; Sakai, Shinsuke ; Hamase, Kenji ; Ikeda, Tatsuhiko ; Matsui, Rakan ; Mita, Masashi ; Horio, Masaru ; Isaka, Yoshitaka ; Kimura, Tomonori. / D -Serine reflects kidney function and diseases In: Scientific reports. 2019 ; Vol. 9, No. 1.
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