Substance P and substance P receptors in bone and gingival tissues

T. Goto, Mizuho A. Kido, Takayoshi Yamaza, Teruo Tanaka

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Substance P (SP) is an important member of the tachykinin family of neuropeptides, which work as neurotransmitters or neuromodulators. Recent advances in the analysis of SP receptors, particularly the neurokinin-1 receptors (NK1-Rs) that have high affinity for SP, have demonstrated that they are distributed not only in the cells of the neuronal or immune systems but also in peripheral cells. Therefore, the effect of SP and its cellular receptors is not limited to the nervous or immune systems, but is more extensive than previously appreciated. SP-like immunoreactive (SP-LI) axons have been localized in both bone and gingival tissue, and SP receptors are widely distributed in osteoclasts, osteoblasts, and junctional epithelial cells, as well as in neutrophils and endothelial cells. The distribution of SP-LI axons and SP receptors suggests that SP may directly modulate bone metabolism and gingival tissue functions through SP receptors.

Original languageEnglish
Pages (from-to)77-85
Number of pages9
JournalMedical Electron Microscopy
Volume34
Issue number2
DOIs
Publication statusPublished - Dec 17 2001

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Neurokinin-1 Receptors
Substance P
Bone and Bones
Neurotransmitter Agents
Axons
Immune System
Tachykinins
Osteoclasts
Neuropeptides
Osteoblasts
Nervous System
Neutrophils
Endothelial Cells
Epithelial Cells

All Science Journal Classification (ASJC) codes

  • Anatomy

Cite this

Substance P and substance P receptors in bone and gingival tissues. / Goto, T.; Kido, Mizuho A.; Yamaza, Takayoshi; Tanaka, Teruo.

In: Medical Electron Microscopy, Vol. 34, No. 2, 17.12.2001, p. 77-85.

Research output: Contribution to journalReview article

Goto, T. ; Kido, Mizuho A. ; Yamaza, Takayoshi ; Tanaka, Teruo. / Substance P and substance P receptors in bone and gingival tissues. In: Medical Electron Microscopy. 2001 ; Vol. 34, No. 2. pp. 77-85.
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